The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

Table 4

Ectonucleotidases (E-NTPDase, E-5-nucleotidase, and adenosine deaminase) in experimental models and patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD).

R Sample	E-NTPDase	E-5-nucleotidase	Adenosine deaminase	Alkaline phosphatase (TNAP)	Reference
Synaptosomes of rats injected with scopolamine	↓ enzymatic activity to ATP (hippocampus and cortex); ↓ enzymatic activity to ADP (hippocampus)	↓ enzymatic activity (hippocampus)	↓ enzymatic activity (hippocampus)	—	[169]
Synaptosomes of rats injected with scopolamine	↑ enzymatic activity to ATP (hippocampus and cortex); ↑ enzymatic activity to ADP (hippocampus)	↓ enzymatic activity (hippocampus)	↑ enzymatic activity (hippocampus)	—	[170]
Hippocampus and plasma from patients with AD	—	—	—	↑ enzymatic activity	[171]
Plasma from patients with AD	—	—	—	↑ enzymatic activity	[172, 173]
Serum from patients with PD	↑ enzymatic activity to ATP; ↑ enzymatic activity to ADP	—	—	—	[174]

Alzheimer’s disease (AD) and Parkinson’s disease (PD).