A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma

Table 2

Univariate and multivariate Cox regression analyses of prognostic factors for overall survival (OS).

Variables	Univariate analyses		Multivariate analyses
	HR (95% CI)	value	HR (95% CI)	value
Gender
Male	0.779 (0.442–1.374)	0.389
Female
Age (years)
>50	0.864 (0.583–1.279)	0.465
≤50
HBs antigen
(+)	0.913 (0.519–1.607)	0.753
(−)
Cirrhosis
Yes	1.876 (1.082–3.250)	0.025	1.994 (1.145–3.475)	0.015
No
AFP (μg/L)
>20	1.458 (0.942–2.258)	0.091
≤20
Tumor size (cm)
>5	1.444 (0.961–2.169)	0.077
≤5
Tumor encapsulation
Complete	1.509 (1.018–2.237)	0.041
None
Microvascular invasion
Yes	2.236 (1.503–3.326)	<0.001	1.552 (1.009–2.389)	0.046
No
Tumor differentiation
I-II	2.539 (1.676–3.846)	<0.001	2.189 (1.394–3.437)	0.001
III-IV
BCLC stage
0 + A	2.181 (1.256–3.789)	0.006
B + C
Fib/Alb ratio
>0.062	2.146 (1.353–3.404)	0.001	2.015 (1.266–3.207)	0.003
≤0.062
ALBI grade
1	1.751 (1.178–2.604)	0.006
2 + 3
NLR
≥2.81	1.546 (1.027–2.327)	0.037
<2.81
PLR
≥115	1.221 (0.817–1.823)	0.330
<115

HR: hazard ratio; 95% CI: 95% confidence interval; BCLC: Barcelona Clinic Liver Cancer. Cox regression analysis, .