Research Article

Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer

Table 3

Top thirty enriched GO terms of DEGs in BC according to value.

TermDescriptionCountGenes

GO:0005615Extracellular space (CC)67NRP1, IL18, EDN1, CXADR, MMP2, ASAH1, CKB, ESF1, GPC4, SERPINE2, WISP3, ANG, PAPPA, HTRA1, IL4R, HMOX1, CCBE1, TGFBI, CFH, TGFA, IL15RA, PDGFC, CAT, SEMA3A, LOXL2, EBI3, MTUS1, GHR, INHBB, VEGFC, VEGFA, SERPINB7, STC1, VCAN, CTSB, CA2, ADAMTS5, CXCL1, WNT5A, CCL2, ENPP2, TNC, CXCL3, CLU, CXCL2, CD109, CXCL8, KIT, NRN1, CCL7, VCAM1, ENO2, COL6A2, PTN, GCNT1, COL18A1, LGALS1, NLGN1, CHI3L2, PXDNL, DKK3, LAMA1, AFP, DKK1, HBEGF, IGFBP2, PLAU
GO:0007157Heterophilic cell-cell adhesion via plasma membrane cell (BP)10VCAM1, PTPRD, CADM1, TENM2, TENM3, NLGN1, NECTIN3, CDH2, CXADR, IL1RAPL1
GO:0071356Cellular response to tumor necrosis factor (BP)14VCAM1, PID1, HDAC4, CCL2, EDN1, CXCL8, NKX3-1, FABP4, HAS2, RORA, ANKRD1, ADAMTS12, ZNF268, CCL7
GO:0071456Cellular response to hypoxia (BP)13SLC8A1, EPAS1, CPEB2, EDN1, RORA, ANKRD1, HMOX1, VEGFA, BNIP3L, PTN, NKX3-1, NDRG1, STC1
GO:0004896Cytokine receptor activity (MF)8IL4R, LIFR, IL15RA, IL13RA1, IL11RA, EBI3, GHR, IL31RA
GO:0050839Cell adhesion molecule binding (MF)10VCAM1, PTPRD, CADM1, TENM2, TENM3, NLGN1, DSP, NECTIN3, ITGA4, CXADR
GO:0006695Cholesterol biosynthetic process (BP)8MSMO1, INSIG2, SQLE, DHCR7, INSIG1, LSS, FDFT1, DHCR24
GO:0001666Response to hypoxia (BP)16CAV1, CCL2, EPAS1, ITGA2, MMP2, DDIT4, ITPR2, VCAM1, VEGFC, CA9, ANG, HMOX1, VEGFA, CAT, LOXL2, PLAU
GO:0030198Extracellular matrix organization (BP)17RECK, COL18A1, HAPLN1, COL13A1, TNC, ITGA2, ITGA4, NID2, DDR2, COL5A1, VCAM1, LAMA1, TGFBI, COL6A2, VCAN, APBB2, MFAP5
GO:0014704Intercalated disc (CC)8SLC8A1, PGM5, ANK2, PKP2, GJA1, DSP, CDH2, CXADR
GO:0001525Angiogenesis (BP)18SAT1, COL18A1, CAV1, NRP1, CCL2, EPAS1, IL18, CXCL8, RORA, JAG1, ESM1, MMP2, VEGFC, ANG, HMOX1, VEGFA, TGFBI, TGFA
GO:0007155Cell adhesion (BP)28CCL2, TNC, CDH2, DDR2, ITGBL1, VCAM1, WISP3, TGFBI, COL6A2, ROBO2, LOXL2, COL18A1, HAPLN1, NLGN1, CD99, ITGA2, PTPRS, CHST4, NECTIN3, ITGA4, NID2, COL5A1, LAMA1, NCAM2, PGM5, CNTN1, VCAN, ADAM12
GO:0005604Basement membrane (CC)10P3H2, COL18A1, LAMA1, TNC, TGFBI, PTN, EFNA5, NID2, LOXL2, COL5A1
GO:0060326Cell chemotaxis (BP)9CXCL1, VCAM1, CCL2, CXCL2, FPR1, HBEGF, LPAR1, KIT, DOCK4
GO:0030165PDZ domain binding (MF)10ADRB1, ATP2B4, CADM1, SNTB1, NLGN1, GJA1, LPAR1, CXADR, SDC2, DOCK4
GO:0008284Positive regulation of cell proliferation (BP)27TNC, EDN1, ESM1, KIT, HMGN5, IL31RA, AKR1C3, TGFA, PTN, NKX3-1, PDGFC, ZNF268, RUNX2, COL18A1, LIFR, DLL1, IRS1, TNS3, VEGFC, HDAC4, VEGFA, KDM4C, HBEGF, PBX1, HAS2, GRK5, F2R
GO:0071347Cellular response to interleukin-1 (BP)9CCL2, EDN1, CXCL8, NKX3-1, HAS2, RORA, ANKRD1, ADAMTS12, CCL7
GO:0003779Actin binding (MF)19ABLIM1, DIXDC1, PHACTR1, MLPH, MICAL2, MYH2, MICAL3, PXK, MYO9A, EPB41L3, EPS8, ANG, LIMCH1, SNTB1, TMOD2, WIPF1, ADD3, STK38L, MYLK
GO:0005886Plasma membrane (CC)145CADM1, JAG1, LPAR1, MMP2, KANK1, IL31RA, PRKAR2B, ATP2B4, ANK2, HTRA1, TGFBI, IL15RA, RRAS, PDGFC, MLKL, PAG1, MTUS1, EBI3, RECK, CA12, LIFR, PTPRS, ABCC10, DLL1, BASP1, IRS1, IL11RA, NCAM2, CD163L1, IGSF3, DSP, EFNA5, ADD3, WNT5A, SLC2A13, IL1R1, CAV1, ENPP2, CSMD3, MME, BDKRB1, PXK, NRN1, PAQR5, P2RY8, PPP1R16A, NDRG1, TBC1D30, RAP1GAP2, LRFN5, CDC42EP3, IL1RAPL1, MSMO1, ADGRG6, ITGA2, ITGA4, PCDH19, DOCK4, RGS2, SLC7A2, PKP2, RGS4, SYTL2, MARCKS, GRK5, DNAJB4, PLAU, CACNA1A, NRP1, PREX1, GJA1, GABBR2, CXADR, DDR2, SDC2, GPC4, SPRY1, SLC1A3, KCNQ3, HMOX1, GUCY1A2, TGFA, MGLL, ANO5, CAT, IL13RA1, JPH1, SLC1A1, ATP8B3, GHR, PTGER4, MICAL3, MPP5, NECTIN3, ALDH3B1, DAPK1, EPB41L3, ADRB1, CA9, STXBP6, CD82, CNTN1, CA2, ADAM12, ARL4C, PMEPA1, PTCHD1, SLC39A10, FPR1, CD109, CDH2, KIT, PLPP3, VCAM1, PLIN2, CLEC2B, DNER, ENO2, CERK, VMP1, EHD1, SLC39A4, FAM127A, PTPRD, SLC8A1, COL13A1, MAP1B, NLGN1, LY6K, CD99, DGKI, ANXA3, ITPR2, KCNN4, DKK1, PLSCR4, SLC16A7, FYN, BNC2, TENM2, GFRA1, HBEGF, CTNS, F2R, VLDLR
GO:0009986Cell surface (CC)29WNT5A, IL1R1, NRP1, CLU, CD109, LPAR1, CXADR, SDC2, VCAM1, KCNQ3, SLC1A3, TGFA, PTN, ROBO2, PDGFC, HHIP, LRFN5, IL1RAPL1, GHR, LGALS1, NLGN1, ITGA2, LY6K, ITGA4, VEGFA, IGSF3, HBEGF, PLAU, F2R
GO:0019221Cytokine-mediated signaling pathway (BP)12CCL2, SOCS2, LIFR, IL15RA, KIT, LRRC15, IL13RA1, IL17RD, IL11RA, EBI3, GHR, IL31RA
GO:0007165Signal transduction (BP)52NRP1, PPARG, IQGAP3, GJA1, IL17RD, DDR2, ANK2, STAC, WISP3, IL4R, INTS6, GUCY1A2, IL15RA, PDE8A, PAG1, SH3GL3, ARHGAP28, OPTN, IRS1, DAPK1, VEGFC, INPP4B, CXCL1, CCL2, GULP1, FPR1, CXCL8, AKAP9, KIT, SP110, CXXC5, MYO9A, CCL7, PDE1A, ARHGAP42, CDC42EP3, IL1RAPL1, EPAS1, LGALS1, DPYSL5, DPYSL2, ITPR2, MGST3, RPS6KA6, EPS8, TENM2, TENM3, HBEGF, IGFBP2, PLCXD2, PLAU, VLDLR
GO:0009612Response to mechanical stimulus (BP)8INHBB, CCL2, PTGER4, TNC, JUND, PPARG, BDKRB1, IGFBP2
GO:0005578Proteinaceous extracellular matrix (CC)18WNT5A, COL18A1, HAPLN1, LTBP1, LGALS1, MMP2, COL5A1, GPC4, LAMA1, WISP3, CCBE1, VEGFA, TGFBI, COL6A2, VCAN, ADAMTS12, TFPI2, ADAMTS5
GO:0030426Growth cone (CC)11NRP1, EPS8, ANG, PREX1, TENM2, TMOD2, DPYSL2, BASP1, APBB2, CXADR, NEFL
GO:0005518Collagen binding (MF)8TGFBI, CCBE1, ADGRG6, ITGA2, NID2, CTSB, LRRC15, DDR2
GO:0007399Nervous system development (BP)19CXCL1, GDA, MAP1B, DPYSL5, NLGN1, MBD5, DPYSL4, JAG1, DPYSL2, NRN1, HDAC4, ST8SIA4, VEGFA, TMOD2, PTN, GFRA1, EFNA5, SIM1, VLDLR
GO:0005515Protein binding (MF)282PRR16, LTBP1, CADM1, TUBB2A, EDN1, RORA, LPAR1, MXI1, MAGEC2, ATP2B4, FLI1, SERPINE2, STAC, INSIG2, CCBE1, INSIG1, INTS6, CFH, CEP290, CCNA1, SH3GL3, RECK, MYH2, LIFR, PTPRS, PRKCDBP, OPTN, BRAP, VEGFC, SPAG4, AAMDC, VEGFA, TGIF1, ADAMTS5, RBP7, IL1R1, TADA3, CCDC92, TAF9B, MME, BDKRB1, RIMS2, MYO9A, PPP1R3C, SYBU, GYS1, TCF4, RAP1GAP2, IL1RAPL1, GCNT1, KLF6, KLF12, KLF13, LGALS1, SMAD6, LAMA1, EPS8, RGS2, PKP2, SYTL2, GRK5, PLAU, NRP1, PPARG, GJA1, RNF182, CKB, FAM168A, SWI5, ZNF350, DMKN, IL4R, TGFA, NEURL1B, HHIP, IL13RA1, BHLHE41, GHR, SH3PXD2A, SNAPC3, TLE4, NECTIN3, RNF175, RBBP6, INHBB, EPB41L3, VCAN, TMSB4X, G0S2, MAP3K14, ARL4C, THAP8, CEP126, CXCL2, FPR1, CXCL8, ZNF365, KIT, MLF1, AMPH, PLEKHG4, COL6A2, ETV1, HBP1, VMP1, WIPF1, CERK, FAM127B, SLC8A1, PDK3, DGKI, NID2, MID1, SNAI2, AFP, DKK1, PLSCR4, FYN, BNIP3L, RASSF2, GFPT2, SH3RF3, PBX1, APBB2, KATNAL1, NR5A2, TEX10, VLDLR, LMO2, CHMP4C, IL18, LMO4, ANKRD1, JAG1, MMP2, KANK1, PRKAR2B, GSTM4, ANK2, ELOVL4, TGFBI, RRAS, IL15RA, ROBO2, MLKL, PDGFC, EBI3, PAG1, NCBP3, TMPRSS15, PID1, SOCS2, HRK, DLL1, BASP1, URB1-AS1, IRS1, TNS3, MAP4K4, HSPB8, TNFAIP8, DSP, RIPK4, GBP3, WNT5A, CAV1, CLU, RRAGA, SOX7, CXXC5, RRAGD, CCL7, PAQR5, PEG10, PELP1, PPP1R16A, CDYL2, JUND, NKX3-1, NDRG1, MBNL3, RUNX2, STK38L, ARHGDIB, REEP6, DIXDC1, EPAS1, RFX5, ITGA2, ITGA4, SELENOM, PSMB8, SREBF2, DOCK4, HDAC4, NREP, PLEKHA5, PRICKLE1, TXNDC16, SLAIN1, PNRC1, BEX5, PTTG1IP, DNAJB4, MYLK, CACNA1A, ATP7B, SAT1, IER3, FOSL2, CYB5R2, MLPH, ATL1, PREX1, GABBR2, CXADR, DDR2, SDC2, SAP30, FAM133A, SPRY1, ANG, HMOX1, TRIM6, SNTB1, MOB3B, TUBA1A, LOXL2, SLC1A1, KHDRBS3, PTGER4, MPP5, CDK9, ALDH3B1, DAPK1, FAM134B, EYA1, ADRB1, PPM1E, CA8, CD82, ZNF711, CLDN1, INPP4B, CTSB, CA2, MATR3, PMEPA1, ABLIM1, PPP4R4, NANOS1, AKAP9, CDH2, GRAMD3, MAP3K7CL, PLPP3, TSC22D1, DNER, KRT8, LACC1, ENO2, SEC22C, ADAMTS12, PIK3R3, EHD1, NEFL, SCO2, PTPRD, COL13A1, MAP1B, DPYSL5, DPYSL4, DPYSL2, RCAN3, PPP1R13L, MGST3, IRF9, ATXN1, KCNN4, ID2, IGFBP2, F2R
GO:0031012Extracellular matrix (CC)19COL18A1, HAPLN1, LTBP1, LGALS1, TNC, CLU, NID2, MMP2, COL5A1, LAMA1, SERPINE2, HTRA1, TGFBI, COL6A2, DSP, VCAN, ADAMTS12, LOXL2, TFPI2
GO:0008201Heparin binding (MF)13CCL2, NRP1, COL13A1, CCL7, COL5A1, SERPINE2, ANG, WISP3, VEGFA, CFH, PTN, HBEGF, ADAMTS5