PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-<i>κ</i>B Inactivation

<div>Treatment with PYR-41 or thalidomide has not increased IL-12 secretion. Murine bone marrow-derived DC (cultured for 4 d) conferred PYR-41 (5 <i>μ</i>M), thalidomide (30 <i>μ</i>M), LPS (10 ng/ml), or DMSO stimulation for 12 hrs, and IL-12 expression was determined by flow cytometry with intracellular IL-12 staining. The positive percentages (a) and the mean fluorescence intensity (b) of analyzed population were shown. Data were presented as the mean ± SEM and one-way ANOVA with Newman–Keuls post test. One representative from 3 independent experiments was shown.</div>

Journal of Immunology Research

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Figure 3: PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-<i>κ</i>B Inactivation 

Figure 3 | PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation 