Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B15:02

Figure 1

Characteristics of peptides presented by HLA-B15:02. (a) Length distribution of low and high binding peptides presented by HLA-B15:02. (b) Length distribution of peptides presented by HLA-B15:02 without treatment (blue), after incubation with CBZ (red) and EPX (green). (c) Preferred AAs of low binding peptides presented by HLA-B15:02. (d) Preferred AAs of high binding peptides presented by HLA-B15:02. All AAs with a frequency higher than 15% (dashed line) are given for position p1-p3, p5, and pΩ. AAs are distinguished into polar positive (blue), polar neutral (green), nonpolar aliphatic (grey), and nonpolar aromatic (purple) AAs.

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