Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B15:02

Figure 3

Alteration of peptides bound to B15:02/CBZ or B15:02/EPX complexes. The alterations of AA frequency after treatment with CBZ (red) and EPX (green) are depicted at p1 (a), p2 (b), p3 (c), and pΩ (d). The graphs for CBZ and EPX were adjusted to the data of AA frequencies obtained without drug treatment (black). The data have been obtained from triplicate experiments.

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