Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms

Figure 4

Dapsone binds more tightly to HLA-B13:01 than to 13:02. Binding models before molecular dynamic simulations for dapsone–HLA-B13:01 (blue) and dapsone–HLA-B13:02 (red), based on observations of the stick representation of their HLA three-dimensional homology models. Dapsone (green) inserts are deeper in HLA-B13:01 (blue) than in HLA-B13:02 (red).