Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars

Table 2

Comparative summary of the differences between the findings of the expression of signaling molecules in cutaneous versus oral mucosa scars.

Type of cells	Cutaneous scars	Oral mucosa scars
TGFbeta1
Mesenchymal cells	74.99% 1+	100% 2+
	3.12% 2+
Endothelial cells	53.12% 1+	100% 2+
	31.25 2+
Macrophages	37.5% 1+	100% 2+
Multinucleated giant cells	52.94% 1+	Not present
Plasma cells	Not present	56.25% 2+
TGFbeta2
Mesenchymal cells	Negative	Negative
Endothelial cells	Negative	Negative
Macrophages	Negative	Negative
Multinucleated giant cells	76.47% 1+	Not present
Plasma cells	Not present	Negative
TGFbeta3
Mesenchymal cells	71.87% 1+	Negative
Endothelial cells	37.5% 1+	100% 2+
	43.75% 2+
Macrophages	21.87% 1+	50.00% 1+
	21.87% 2+	50.00% 2+
Multinucleated giant cells	29.41% 1+	Not present
	29.41% 2+
Plasma cells	Not present	56.25% 2+
TNFalpha
Mesenchymal cells	46.87% 1+	Negative
Endothelial cells	25.00% 1+	Negative
Macrophages	43.74% 1+	Negative
Multinucleated giant cells	70.58% 1+	Not present
Plasma cells	Not present	28.12% 1+
		28.12% 2+
PDGF BB
Mesenchymal cells	43.75% 1+	Negative
	6.25% 2+
Endothelial cells	59.36% 1+	100% 2+
	21.87 2+
Macrophages	65.63% 1+	100% 2+
	21.87% 2+
Multinucleated giant cells	70.58% 1+	Not present
	23.53% 2+
Plasma cells	Not present	56.25% 2+
FGF1
Mesenchymal cells	34.37% 1+	Negative
	15.62% 2+
Endothelial cells	52.38% 1+	100% 2+
	16.37% 2+
Macrophages	71.87% 1+	100% 1+
	6.25% 2+
Multinucleated giant cells	82.34% 1+	Not present
	11.76% 2+
Plasma cells	Not present	56.25% 1+