The Effect of Immunosuppressive Drugs on MDSCs in Transplantation

Figure 3

The different modulatory effects of mTOR inhibitors on MDSCs. The regulatory effects of mTOR inhibition on MDSCs were controversial so far. The positive and negative effects of rapamycin on MDSCs were both illustrated here. This inconsistency may be due to different animal models or different doses and modes of rapamycin administration. Rapa, rapamycin; Arg1, arginase 1; iNOS, inducible nitric oxide synthase; HK, hexokinase; PFK, phosphofructokinase; PKM, pyruvate kinase muscle isozyme; LDHA, lactate dehydrogenase-α.