Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice

Figure 1

Injections of immature DCs pulsed with subdominant and ignored dominant β cell antigenic peptides significantly delay T1D in NOD mice. (a) Nine-week-old NOD mice received subcutaneous injection of PBS, unpulsed DCs, or subdominant determinant-pulsed DCs, once a week for 3 weeks. Then, the mice were monitored for diabetes onset till 27 weeks of age. (b) Nine-week-old NOD mice received subcutaneous injection of PBS, unpulsed DCs, or ignored determinant peptide-pulsed DCs, once a week for 3 weeks. Then, the mice were monitored for diabetes onset till 30 weeks of age. Kaplan–Meier survival curves were depicted, and statistical analysis was performed using Log-Rank test; is considered statistically significant.

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