Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice

Figure 2

DC therapy-induced T1D protection can be maintained by ignored or subdominant determinant antigenic peptide boosters. Nine-week-old NOD mice received three weekly injections of PBS, unpulsed DCs, or DCs pulsed with DD, SD, or ID peptides. Thereafter, the mice received the corresponding treatment every other week until the study ended. Diabetes onset was monitored once a week. values represent difference compared between PBS and treatment groups.