Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds
Table 1
Strictly standardized mean difference (SSMD) values and major functions of 33 hits at 20 μM from the primary screening of the Epigenetics Screening Library.
Compound name
CAS number
SSMD
Major function
SAHA
149647-78-9
23.22
HDAC inhibitor
Trichostatin A
58880-19-6
22.09
HDAC inhibitor
Pyroxamide
382180-17-8
18.1
HDAC inhibitor
LAQ824
404951-53-7
17.98
HDAC inhibitor
Panobinostat
404950-80-7
17.61
HDAC inhibitor
CAY10398
193551-00-7
16.72
HDAC inhibitor
SB939
929016-96-6
11.16
HDAC inhibitor
M 344
251456-60-7
11.07
HDAC inhibitor
4-Iodo-SAHA
1219807-87-0
10.86
HDAC inhibitor
Pimelic diphenylamide 106
937039-45-7
10.38
HDAC inhibitor
CAY10603
1045792-66-2
10.36
HDAC inhibitor
CUDC-101
1012054-59-9
10.23
HDAC/EGFR/HER2 inhibitor
CBHA
174664-65-4
9.9
HDAC inhibitor
Scriptaid
287383-59-9
9.87
HDAC inhibitor
HC toxin
83209-65-8
9.72
HDAC inhibitor
Apicidin
183506-66-3
9.71
HDAC inhibitor
Oxamflatin
151720-43-3
9.54
HDAC inhibitor
ITF-2357
732302-99-7
8.19
HDAC inhibitor
Coumarin-SAHA
1260635-77-5
7.78
HDAC inhibitor
MS-275
209783-80-2
7.39
HDAC inhibitor
HPOB
1429651-50-2
7.2
HDAC inhibitor
Chidamide
743420-02-2
6.38
HDAC inhibitor
3,3-Diindolylmethane
1968-05-4
5.52
HDAC/DNMT inhibitor
trans-Resveratrol
501-36-0
4.71
HDAC inhibitor
Tubacin
537049-40-4
4.06
HDAC inhibitor
UNC0642
1481677-78-4
4.04
HMT inhibitor
RSC-133
1418131-46-0
3.72
HDAC/DNMT inhibitor
UNC1215
1415800-43-9
3.67
L3MBTL3 inhibitor
UNC0224
1197196-48-7
3.39
HMT inhibitor
S-Adenosylhomocysteine
979-92-0
3.21
DNMT inhibitor
MC 1568
852475-26-4
3.05
HDAC inhibitor
2-PCPA (hydrochloride)
1986-47-6
3.02
LSD1 inhibitor
EX-527
49843-98-3
3.0
HDAC inhibitor
Abbreviations: HDAC: histone deacetylase; EGFR: epidermal growth factor receptor; HER2: human epidermal growth factor receptor 2; DNMT: DNA methyltransferase; HMT: histone methyltransferase; L3MBTL3, lethal (3) malignant brain tumor-like protein 3, a histone methyl-lysine binding protein; LSD1: histone lysine-specific demethylase 1.
