Research Article

Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds

Table 2

Strictly standardized mean difference (SSMD) values and major functions of 10 hits at 20 μg/ml from the primary screening of two natural product libraries (BIOMOL International).

Compound nameCAS numberSSMDMajor epigenetic function

Homobutein34000-39-09.32HDAC inhibitor
Ikarugamycin36531-78-99.3Unknown
Cynaroside5373-11-57.79Unknown
(−)-Depudecin139508-73-95.63HDAC inhibitor
Sanguinarine2447-54-35.36Unknown
α-Chaconine20562-03-24.36Unknown
Apicidin183506-66-34.13HDAC inhibitor
Lavendustin A125697-92-94.11Unknown
Coumestrol479-13-03.91Unknown
HC toxin83209-65-83.16HDAC inhibitor