Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds

Table 3

Chemical structures and classification of 13 compounds giving a minimum of 5-fold increase in the luciferase activity in stable porcine IPEC-J2/PBD3-luc luciferase reporter cells.

Chemical name	Chemical structure	Class of HDAC inhibitor	Types of HDAC inhibited
SAHA		Hydroxamate	Class I, II, and IV HDACs
4-Iodo-SAHA		Hydroxamate	Class I, II, and IV HDACs
Coumarin-SAHA		Hydroxamate	Class I, II, and IV HDACs
Trichostatin A		Hydroxamate	Class I, II, and IV HDACs
LAQ824		Hydroxamate	Class I and II HDACs
Panobinostat		Hydroxamate	Class I, II, and IV HDACs
SB939		Hydroxamate	Class I, II, and IV HDACs
CBHA		Hydroxamate	Class I and II HDACs
ITF-2357		Hydroxamate	Class I and II HDACs
HC toxin		Cyclic tetrapeptide	Class I and II HDACs
Apicidin		Cyclic tetrapeptide	Class I and II HDACs
(−)-Depudecin		Epoxide	Class I HDACs
Sanguinarine		N/A	N/A