Research Article
Expression of PD-1 on CD4+ Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer
Table 2
The relationship between CD4/PD-1 TILs and clinical characteristics.
| | CD4+TILs | | CD4+/PD1+TILs | | CD4+/PD1−TILs | |
| Age, median (IQR)∗ | | 0.024 | | 0.069 | | 0.045 | ≤55 | 56 (67) | 17 (38) | 32 (43) | >55 | 40 (54) | 13 (22) | 25 (29) | Histological grade, median (IQR)∗∗ | | 0.083 | | 0.136 | | 0.092 | I | 40 (48) | 13 (29) | 17 (26) | II | 45 (65) | 13 (32) | 32 (33) | III | 55 (82) | 22 (40) | 32 (58) | Vascular invasion, median (IQR) | | 0.316 | | 0.914 | | 0.275 | No | 42 (63) | 15 (32) | 26 (35) | Yes | 54 (47) | 16 (25) | 32 (22) | Nerve invasion, median (IQR)∗ | | 0.601 | | 0.826 | | 0.365 | No | 44 (48) | 16 (28) | 27 (28) | Yes | 54 (88) | 14 (44) | 32 (53) | Axillary lymph node metastasis, median (IQR)∗ | | 0.469 | | 0.725 | | 0.169 | No | 67 (71) | 20 (26) | 50 (47) | Yes | 57 (48) | 14 (45) | 30 (33) |
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∗Wilcoxon test. ∗∗Spearman correlation test.
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