Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis

Table 3

Correlations between depressive symptoms and serum cytokine levels.

		Pseudo	AICc	Coefficient	Odds ratio (95% CI)	value
Rheumatoid arthritis	()
IL-6 (pg/mL), mean ± SD	44.04 ± 104.39	1.000	73.80	0.002	1.00 (1.00-1.00)	0.132
IL-10 (pg/mL), mean ± SD	4.12 ± 2.97	1.000	68.99	0.121	1.13 (1.03–1.22)	0.005
TNF-alpha (pg/mL), mean ± SD	109.92 ± 151.85	1.000	75.19	0.001	1.00 (1.00-1.00)	0.430
Lupus	()
IL-6 (pg/mL), mean ± SD	2.81 ± 2.18	1.000	83.69	0.055	1.06 (0.96–1.15)	0.229
IL-10 (pg/mL), mean ± SD	6.76 ± 4.06	1.000	76.47	−0.088	0.92 (0.86–0.97)	0.006
TNF-alpha (pg/mL), mean ± SD	60.66 ± 102.38	1.000	83.56	−0.001	1.00 (1.00-1.00)	0.243
Depressive disorder	()
IL-6 (pg/mL), mean ± SD	1.30 ± 2.23	0.970	143.99	0.070	1.07 (1.01–1.13)	0.011
IL-10 (pg/mL), mean ± SD	9.18 ± 15.66	0.962	146.13	0.008	1.01 (1.00-1.02)	0.059
TNF-alpha (pg/mL), mean ± SD	38.43 ± 67.75	0.962	146.01	0.002	1.00 (1.00-1.00)	0.048
Healthy controls	()
IL-6 (pg/mL), mean ± SD	1.11 ± 1.34	0.653	102.02	0.014	1.01 (0.84–1.18)	0.869
IL-10 (pg/mL), mean ± SD	3.07 ± 3.78	0.712	98.70	0.047	1.05 (1.00-1.09)	0.047
TNF-alpha (pg/mL), mean ± SD	33.77 ± 53.08	0.706	99.05	−0.005	1.00 (0.99–1.00)	0.109