Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer

Table 1

Regulation of MDSCs in lung cancer.

Treatment	Mouse model versus patients	Effect on MDSCs	References
Gemcitabine	Mouse models	Inhibition of MDSC expansion	[29]
Retinoic acid	Mouse models	Promotion of the differentiation of immature MDSCs	[54]
WGP	Mouse models	Promotion of the differentiation and maturation of MDSCs	[55]
Cyclooxygenase 2 inhibitor	Mouse models	Inhibition of the suppressive effects of MDSCs	[11, 56]
CSF-1 receptor antagonist(GW2580)	Mouse models	Inhibition of the recruitment of MDSCs	[57]
Anti-c-KIT	Mouse models	Inhibition of the amplification of MDSCs	[58]
Anti-Gr-1 or anti-Ly6G antibodies	Mouse models	Depletion of MDSCs	[59]
Indomethacin	Mouse models	Inhibition of the suppressive effects of MDSCs	[60]
ATRA	Patients	Inhibition of MDSCs expansion	[61]
Triterpenoids	Mouse models and patients	Inhibition of the suppressive effects of MDSCs	[62]