| | Associated drug | HLA allele | Hypersensitivity reactions | Ethnicity | Reference |
| | Aromatic anticonvulsants | | Carbamazepine | B15:02 | SJS/TEN | Han Chinese, Thai, Indian, Malaysian, Vietnamese, Singaporean, Hong Kongese | [45, 82, 83, 226–230] | | A31:01 | DRESS | Han Chinese, European, Spanish | [86, 87, 231] | | A31:01 | DRESS/SJS/TEN | Northern European, Japanese, Korean | [88–90] | | B15:11 | SJS/TEN | Han Chinese, Japanese, Korean | [89, 232, 233] | | B59:01 | SJS/TEN | Japanese | [234] | | B38:01 | SJS/TEN | Spanish | [231] | Oxcarbazepine
Phenytoin | B15:02 | SJS/TEN | Han Chinese, Thai | [81, 84] | | B15:02 | SJS/TEN | Han Chinese, Thai | [81, 83] | | B15:02, B13:01, B51:01 | SJS/TEN | Han Chinese, Japanese, Malaysian | [91] | | A33:03, B38:02, B51:01, B56:02, B58:01, C14:02 | SJS/TEN | Thai | [235] | | B51:01 | DRESS | Thai | [235] | | B15:13 | DRESS/SJS/TEN | Malaysian | [236] | | CYP2C93 | DRESS/SJS/TEN | Han Chinese, Japanese, Malaysian | [91] | | CYP2C93 | SJS/TEN | Thai | [235] | Phenobarbital
Lamotrigine | B15:02 | SJS/TEN | Han Chinese | [81, 85, 237] | | B38; B58:01, A68:01, Cw07:18 | SJS/TEN | European | [93, 238] | | B38:01 | SJS/TEN | Spanish | [231] | | A31:01 | SJS/TEN | Korean | [239] | | A24:02 | DRESS/SJS/TEN | Spanish | [231] | | Allopurinol | B58:01 | DRESS/SJS/TEN | Han Chinese, Thai, Japanese, Korean, European | [92–96] | | Antiretroviral drugs | | Abacavir | B57:01 | HSS | European, African | [98, 99] | | Nevirapine | DRB101:01 | DRESS | Australian | [240] | | B35:05 | DRESS | Thai | [101] | | B14:02, Cw08:01, Cw08:02 | HSS | Sardinian, Japanese | [102, 241] | | C04:01 | DRESS/SJS/TEN | Malawian | [242] | | Antibiotics | | Beta-lactam | DR9, DR14.1, DR17, DR4 | Immediate-type drug hypersensitivity | Chinese | [243] | | DRA rs7192, DRA rs8084 | Immediate-type drug hypersensitivity | Spanish, Italian | [66] | | Cotrimoxazole | B15:02, C06:02, C08:01 | SJS/TEN | Thai | [244] | | Dapsone | B13:01 | HSS | Han Chinese | [105] | | Sulfamethoxazole | B38:02 | SJS/TEN | European | [93] | | Sulfonamide | A29, B12, DR7 | TEN | European | [245] | | NSAIDs | | Aspirin | DRB113:02, DRB106:09 | Urticaria/angioedema | Korean | [74] | | Aspirin and other NSAIDs | DRB111 | Urticaria/angioedema and hypotension/laryngeal edema | Spanish | [246] | | Aspirin and other NSAIDs | B44, Cw5 | Chronic idiopathic urticaria | Italian | [75] | | Oxicam NSAIDs | B73:01 | SJS/TEN | European | [93] | | Other drugs | | Methazolamide | B59:01, CW01:02 | SJS/TEN | Korean, Japanese | [108] |
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