LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue

Figure 4

Literature mining results of top 8 differentially expressed proteins in degree. (a) Clustering analysis of LCK, CD3G, B2M, IFNG, CD3D, TNF, VAV1, and CD3E in previous studies. In the heat map, each row represents a gene, and each column represents a biological keyword. The color black means that the keyword has not been reported in this gene, and the color light green means that this keyword is related to this gene. Hot genes are mainly clustered in immune response, cell activation, cell differentiation, cell surface, T-cell activation, signal transduction, and plasma membrane. (b) Cocitation network of hot genes. In the cocitation network, all of the 8 genes were closely interacted. The numbers noted on the line indicate the number of studies cocited.

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