LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue

Figure 5

Protein-protein interaction (PPI) network of important proteins. Upregulated proteins are in red, and downregulated ones are in blue. The PPI network consists of 27 upregulated proteins including LCK, CD3G, CD3E, CD3D, IFNG, VAV1, TNF, B2M, CXCR3, CCR5, CCL5, CXCL9, CXCL10, CXCR4, GNG2, IL1B, IL12B, IL2RB, IL2RA, IL2RG, STAT1, CD8A, CD86, PTPRC, PIK2CG, CD44, and HLA-DPA1 and 1 downregulated protein EGF. LCK, CD3G, and IFNG are identified as hub proteins.