Research Article

Intravenous Cyclophosphamide Therapy for Anti-IFN-Gamma Autoantibody-Associated Mycobacterium abscessus Infection

Table 1

Clinical data and outcomes among disseminated M. abscessus-infected patients treated with intravenous cyclophosphamide (IVCY).

Patient no.Age/sexOrgan involvementTreatment duration before IVCY (month)Other opportunistic infectionOral antibioticParenteral antibiotic prior to IVCY/duration (week)No. of IVCY cycle receivedInitial IFN-γ Ab titerIFN-γ Ab titer at the end of treatmentFollow-up after IVCY (month)Outcome

152/MLymph nodes, lung, spleen19Tuberculosis lung, Herpes zoster, penicilliosisClarithromycin, ofloxacin(1) Cefoxitin/2
(2) Imipenem/2
(3) Imipenem/4
(4) Imipenem/4
51 : 100,0001 : 50,000Not applicableUnevaluable: lost to follow-up and died 3 months later

254/MLymph nodes, lung15NoneClarithromycin, ciprofloxacin(1) Imipenem/2
(2) Imipenem/4
(3) Imipenem/4
141 : 200,0001 : 5,00057Response: cured with discontinued NTM treatment

357/MLymph nodes, lung, liver10Tuberculosis lungAzithromycin, ciprofloxacin(1) Imipenem/4
(2) Imipenem/4
(3) Imipenem/4
161 : 200,0001 : 1,00044Response: cured with discontinued NTM treatment

441/MLymph nodes, nasal septum19MelioidosisClarithromycin, ofloxacin(1) Imipenem/2
(2) Imipenem/4
(3) Imipenem/4
(4) Imipenem/4
171 : 200,0001 : 1,00060Response: stable on NTM treatment without hospitalization for parenteral antibiotic

554/FLymph nodes, skin12NoneClarithromycin, ciprofloxacin(1) Imipenem/4
(2) Imipenem/4
(3) Imipenem/4
(4) Imipenem/4
171 : 100,0001 : 1,00028Response: stable on NTM treatment without hospitalization for parenteral antibiotic

665/MLymph nodes, lung, femur48SalmonellosisClarithromycin, ciprofloxacin(1) Imipenem/4
(2) Imipenem/4
(3) Imipenem/4
171 : 100,0001 : 5,00044Response: stable on NTM treatment without hospitalization for parenteral antibiotic

734/MLymph nodes, lung, multiple bones15Cryptococcosis, tuberculosis boneClarithromycin, ciprofloxacin, linezolid(1) Imipenem/2
(2) Imipenem/2
(3) Imipenem/4
(4) Imipenem/4
(5) Imipenem/4
(6) Imipenem/4
251 : 200,0001 : 50,00045Not response: relapsed with hospitalization for parenteral antibiotic

820/FLymph nodes, skin, lung, liver, spleen, pancreas, humerus26Cryptococcosis, Herpes zosterAzithromycin, ofloxacin, doxycycline, linezolid(1) Imipenem/4
(2) Imipenem/4
(3) Imipenem/4
201 : 400,0001 : 50,00041Not response: relapsed twice with hospitalization for parenteral antibiotic