Biological Properties and the Role of IL-25 in Disease Pathogenesis

Figure 5

The relationship between IL-25 and other diseases. IL-25 can activate macrophages, transform macrophages into M2 type, enhance its intake of fat, promote fat decomposition, inhibit fat synthesis, and significantly improve NAFLD. IL-25 enhances Th2 immune responses, inhibits Th1 immune responses, sustains ILC2 homeostasis, and consequently improves parasitic infection. IL-25 is associated with FH as well.