Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes

Table 1

Changes in gene expression in neutrophils phagocytizing iRBCs as determined by DNA microarray analysis and qRT-PCR.

Gene	GenBank accession number	Fold change^†
		Microarray	qRT-PCR
RIT2	NM_002930	780.63	51.35 ± 14.44
MLLT10	NM_004641	287.92	6.20 ± 2.67
CTSL	NM_001912	87.55	41.10 ± 26.38
CYGB	NM_134268	39.87	9.65 ± 5.92
ELN	NM_000501	39.86	30.72 ± 19.00
SOCS3	NM_003955	37.19	6.90 ± 2.70
IRG1	NM_001258406	22.05	5.39 ± 1.80
VIT	NM_053276	18.94	8.41 ± 4.30
CISH	NM_145071	18.19	24.65 ± 3.22
CXCL10	NM_001565	17.69	10.83 ± 7.63
CD64	XM_005244958	10.56	8.24 ± 1.30

^†Fold change indicates the mean expression level of the gene in neutrophils cocultured with Plasmodium falciparum-parasitized erythrocytes normalized to that in neutrophils cocultured with normal red blood cells.