Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus

Table 6

Predicted conformational B-cell epitopes of the polyprotein of OROV.

Epitope no.	Residues and their positions	No. of residues	Score	3D structure
1.	V992, K993, K994, A995, V996, Y997, K998, A999, Q1000, Y1001, Q1002, K1003, V1004, T1006, T1007, G1008, P1009, S1010, I1011, S1012, I1013, N1014, I1015, E1016, H1017, N1018, E1019, K1020, C1021, T1022, G1023, H1024, C1025, P1026, E1027, K1028, I1029, P1030, A1031, K1032, E1033, G1034, W1035, L1036, T1037, K1040, E1041, S1044, S1045, W1046, G1047, C1048, E1049, E1050, Y1051, G1052, C1053, L1054, A1055, I1056, D1057, T1058, G1059, C1060, L1061, Y1062, G1063, S1064, C1065, Q1066, D1067, V1068, I1069, R1070, P1071, E1072, L1073, D1074, I1075, K1077, K1078, I1079, G1080, S1081, E1082, D1110, K1111, I1140	88	0.906	Figure 5(a)
2.	Y76, R77, I80, V81, D83, W84, S85, E86, C87, N88, P89, V90, L91, D92, K93, L94, G95, N96, M98, N105, G106, H107, L108, V109, P110, R111, M112, Y113, T114, C115, R116, A117, A118, C119, D120, I121, R122, L123, N124, K125, D126, N127, A128, E129, I130, I131, L132, S133, S134, T135, K136, L137, N138, H139, F140, E141, I142, V143, G144, T145, T146, S147, T148, S149, G150, W151, F152, K153, N154	69	0.895	Figure 5(b)
3.	M738, S739, P740, S742, C760, K761, M762, D763, N764, K765, Y766, K767, A768, F769, D770, W771, P772, E773, I774, E775, T776, V777, Q778, K779, G780, Q781, K782, L783, C784, L785, G786, D787, S788, H789, C790, K810, E811, S812, F813, T814, A815, Q816, P817	43	0.875	Figure 5(c)
4.	Y563, T565, E566, C567, E568, M569, L570, S571, L572, K573, K574, N575, S576, G577, P578	15	0.864	Figure 5(d)
5.	G43, L44, G45, E46, I47, C48, V49, K50, D51, D52, I53, S54, I55	13	0.845	Figure 5(e)
6.	I1385, I1388, V1389, L1390, V1394, L1395, L1396, P1397, I1398, G1399, R1400, L1401, L1402, K1403, A1404, F1405, L1406, I1407, K1408, E1412	20	0.843	Figure 5(f)
7.	M292, D295, C296, L297, G298	5	0.838	Figure 5(g)
8.	P332, I333, A334, G335, E336, R337, M338, Y339, K340, E342, E343, A345, D346, F387, N388, Y389, L390, S397, C398, S399, M400, C401, G402, L403, I404, H405, Y406, R407, P408, G409, L410, K411, V412, D413, L414, T415, K416, T417, N418, K419, C420, G421, S422	43	0.837	Figure 5(h)