Silicone-Induced Granuloma of Breast Implant Capsule (SIGBIC): Histopathology and Radiological Correlation

Table 1

Main keys for the diagnosis of silicone-induced granuloma of breast implant capsule (SIGBIC) by breast magnetic resonance imaging (BMRI) and histology.

SIGBIC	BMRI	Histology
(1) Intracapsular	(i) Restricted to intracapsular space; (ii) Mass with hypersignal at T2-weighted sequences; (iii) Black-drop signal; (iv) Late contrast enhancement	(i) Extracellular silicone; (ii) Lower population of aggregate lymphocytes; (iii) Moderate chronic inflammatory process
(2) Extracapsular extension	(i) Same findings from intracapsular; (ii) Pericapsular edema; (iii) Lymph node involvement; (iv) Early contrast enhancement of the extracapsular content	(i) Extracellular and intracellular silicone; (ii) Predominance of extracellular silicone; (iii) Germinal centers of lymphocytes; (iv) Diffuse infiltration by lymphocytes at the fibrous capsule
(3) Mixed with seroma	(i) Same findings from the others; (ii) Voluminous seroma	(i) Extracellular and intracellular silicone; (ii) Predominance of intracellular silicone; (iii) More severe infiltration by lymphocytes at the fibrous capsule; (iv) Seroma of histiocytes and lymphocytes