Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review

Table 1

Diagnostic criteria for IgG4-related disease (modified after Umehara et al. [4]).

Diagnosis	Criteria
Definitive	Diffuse or local swelling or multiple organs
	Serum IgG4 levels ≥ 135 mg/dL
	Histology:
	(1) Lymphoplasmacytic infiltrate and fibrosis; (2) IgG4^+ plasma cells: ratio of IgG4^+/IgG^+ cells > 40%, and >10 IgG4^+ plasma cells/high-power field
Probable	Diffuse or local swelling or multiple organs
	Histology:
	(1) Lymphoplasmacytic infiltrate and fibrosis; (2) IgG4^+ plasma cells: ratio of IgG4^+/IgG^+ cells > 40%, and >10 IgG4^+ plasma cells/high-power field
Possible	Diffuse or local swelling or multiple organs
	Serum IgG4 levels ≥ 135 mg/dL