Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies

Figure 2

Illustrative image describing anti-PD-1/PD-L1 therapy combined with CAR-T cells. T cells are obtained and isolated from the patients. These T cells are transformed with chimeric antigen receptor (CAR) gene by lentiviruses. The CAR-T cells are expanded in vitro and finally infused back to patients. After the CAR-T cells transferred into patients, the CAR-T cells are able to recognize target gene-positive tumor cells. Meanwhile, CAR-T cells can secrete anti-PD-1/PD-L1 antibody and combine with foreign anti-PD-1/PD-L1 antibody to recognize and kill the tumor cells.