Differences of Clonogenic Mesenchymal Stem Cells on Immunomodulation of Lymphocyte Subsets

Table 1

Cytokine concentrations (pg/mL) in unstimulated cocultures of MSC clones with PBMCs (mean ± SD).

	Concentration of cytokines (pg/mL) in PBMC : MSC cocultures
	w/o MSC	1.10	1.22	1.7	3.10	3.5
IL-1β	253.6 (248.7)^a	996.2 (434.1)^bc	788.0 (490.8)^b	1133.6 (689.8)^c	1071.4 (440.5)^bc	919.4 (425.1)^bc
TNF-α	106.4 (72.5)^a	14.6 (12.8)^b	7.3 (6.7)^b	29.0 (9.5)^ab	18.4 (10.4)^b	5.5 (9.6)^b
IL-10	2.1 (3.6)	129.8 (35.3)	148.6 (76.8)	150.7 (109.7)	128.6 (95.1)	161.7 (89.0)
IFN-γ	3.9 (6.7)	—	—	45.7 (79.1)	59.5 (72.5)	—
IL-4	3.6 (6.2)	—	3.6 (6.2)	—	7.2 (12.4)	—
IL-2	30.6 (52.9)	—	32.9 (57.0)	—	16.9 (29.2)	—
IL-22	—	18.0 (31.1)	—	—	—	—
IL-13	—	10.9 (18.9)	—	—	—	—
IL-17A	—	—	—	—	3.8 (6.6)	—
IL-9	1.0 (1.7)	—	—	—	—	—
IL-5	—	—	—	—	—	—
IL-12p70	—	—	—	—	—	—

Groups () containing the same letters are not statistically different for ANOVA (LSD), .