Differences of Clonogenic Mesenchymal Stem Cells on Immunomodulation of Lymphocyte Subsets

Table 2

Cytokine concentrations (pg/mL) in phytohemagglutinin-stimulated (10 μg/mL) cocultures of MSC clones with PBMCs (mean ± SD).

	Concentration of cytokines (pg/mL) in PBMC : MSC cocultures
	w/o MSC	1.10	1.22	1.7	3.10	3.5
IL-1β	2055.1 (151.5)^a	2344.6 (247.9)^a	2025.1 (498.3)^a	2809.0 (662.8)^b	2770.9 (712.0)^b	2136.7 (740.2)^a
TNF-α	416.8 (23.5)^a	32.4 (7.2)^c	42.5 (26.6)^c	208.6 (101.8)^b	79.9 (29.7)^c	14.1 (24.4)^c
IL-10	819.4 (433.2)^a	352.2 (62.4)^b	531.8 (190.3)^bc	783.1 (312.2)^ac	455.0 (45.3)^b	531.4 (148.0)^bc
IFN-γ	2512.4 (1829.8)^a	359.9 (252.7)^b	270.3 (207.2)^b	3180.4 (1441.5)^a	2093.2 (1854.4)^a	186.1 (177.3)^b
IL-4	1.9 (3.3)	—	—	—	—	—
IL-2	27.8 (31.6)	18.9 (32.8)	18.9 (32.8)	22.5 (39.0)	—	—
IL-22	51.53 (77.31)^ab	—^a	12.5 (21.7)^ab	40.7 (70.5)^ab	81.3 (71.0)^b	—^a
IL-13	998.0 (246.7)^a	—^b	110.7 (96.7)^bc	123.2 (108.4)^bc	210.6 (325.7)^c	—^b
IL-17A	549.3 (330.5)^ab	350.1 (90.4)^a	936.2 (508.1)^cd	906.6 (613.8)^cd	723.3 (307.0)^bc	1017.5 (403.0)^d
IL-9	527.3 (126.4)^a	—^b	20.2 (20.6)^b	119.3 (117.2)^c	45.7 (73.9)^bc	2.9 (2.6)^b
IL-5	168.2 (120.8)^a	10.3 (17.9)^b	58.5 (50.8)^bc	63.9 (50.4)^bc	83.4 (110.2)^c	31.4 (54.4)^bc
IL-12p70	—	—	—	37.4 (22.8)	—	—

Groups () containing the same letters are not statistically different for ANOVA (LSD), .