FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling

Figure 1

FGFRL1 expression is increased in OC. (a) The mRNA level of FGFRL1 is unregulated in SBOT, LGSOC, and HGSOC compared with OSE in the GSE27651 dataset. Comparison of mRNA expression levels of FGFRL1 in OSE and SOC tissues in the GSE18520 (b) and GSE12470 datasets (c). (d) The representative IHC staining of FGFRL1 in OC and noncancerous samples in the TMA. Scale bar, 50 μm. (e) Score of the IHC staining in the TMA of OC. (f) Correlation between FGFRL1 expression and the patient overall survival was conducted in TCGA. (g) Comparisons of overall survival between the lower FGFRL1 expression group and the higher FGFRL1 expression group in patients with advanced grade (II-III). SBOT: serous borderline ovarian tumors; LGSOC: low-grade serous ovarian carcinomas; HGSOC: high-grade serous ovarian carcinomas; OSE: ovarian surface epithelia; SOC: serous ovarian carcinomas; OCCC: ovarian clear cell carcinoma; OEC: ovarian endometrioid adenocarcinoma; MOC: mucinous ovarian carcinoma; LN: lymphatic node. ; .

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