Review Article

MicroRNA in Sjögren’s Syndrome: Their Potential Roles in Pathogenesis and Diagnosis

Table 1

miRNA expression profiling in SS patients.

miRNAmiRNA sourceExpressionReference

miR-300, miR-609, miR-3162-3p, miR-4701-5pMonocytesUpregulated(Williams et al. [81])
miR-181aSGUpregulated(Kapsogeorgou et al. [53])
miR-200bSGEC
miR-223PBMCs
let-7bSGECDownregulated
miR-146a/bPBMCsUpregulated(Zilahi et al. [74])
miR-17-92MSGDownregulated(Alevizos and Illei [70])
miR-144-5p, miR-34a-5p, miR-425-3p/-5p, miR-145-5p, miR-21-3p, miR-18a-5p, miR-769-5p, miR-190a, miR-15a-5p, miR-106a-5p, miR-424-3p, miR-20b-5p, miR-16-1-3p, let-7e-5p, let-7d-5p, miR-126-3p/-5p, miR-186-5p, miR-20a-5p, miR-146a-5p, miR-484, miR-191-5p, miR-26a-5p, miR-222-3pPBMCsUpregulated(Chen et al. [75])
miR-150-5pDownregulated
miR-155-5p, miR-222-3p, miR-146a-5p, miR-28-5pT lymphocytesUpregulated(Wang-Renault et al. [78])
let-7d-3p, miR-30c-5p, miR-378a-3pDownregulated
miR-222-3pB lymphocytesUpregulated
miR-378a-3p, miR-26a-5p, miR-30b-5p, miR-19b-3pDownregulated
miR-181a, miR-16SGDownregulated(Wang et al. [82])
miR-146aPBMCsUpregulated(Shi et al. [76])
miR-155Downregulated
miR-146a, miR-155PBMCsUpregulated(Pauley et al. [77])
miR-181aPBMCsUpregulated(Peng et al. [83])
miR-155, miR-181aSGECUpregulated(Le Dantec et al. [26])

SG: salivary glands; SGEC: cultured salivary glands epithelial cells; PBMCs: peripheral blood mononuclear cells; MSG: minor salivary glands.