Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions

Table 1

Predictable and unpredictable reactions to systemic medications: general considerations [19].

Predictable drug effects	Unpredictable drug reactions
(i) Expected pharmacological action	(i) Drug intolerance
(ii) Unavoidable side effects	(ii) Idiosyncracy
(iii) Drug toxicity	(iii) Immunologically mediated
(iv) Adverse effects of known drug-drug interactions

Known drug reactions occurring at much lower doses or blood concentration. Unexpected drug reactions which do not occur in the vast majority of subjects taking this particular medication.