Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context
Table 2
Occurrence of substitutions in amino acid positions 70 and 91 of the nucleocapsid (core) protein of HCV 1b in the samples collected from the general population of the Russian Federation during the routine blood tests.
Number of cohort
Federal District of Russia
City
Date of collection of samples
Number of HCV 1b sequences
Mutations found in aa position 70, n (%)
Mutations found in aa position 91, n (%)
Mutations found in aa positions 70 and 91, n (%)
Without mutations in aa positions 70 and 91, n (%)
1
Central
Moscow
2008
5
1 (20.0)
4 (80.0)
1 (20.0)
1 (20.0)
2009
6
1 (16.7)
5 (83.3)
0 (0)
0 (0)
2011
17
10 (58.9)
15 (88.2)
9 (53.0)
1 (5.9)
2014
21
7 (33.3)
16 (76.2)
6 (28.6)
4 (19.0)
2008–2014
49
19 (38.7)
40 (81.6)
17 (34.7)
7 (14.2)
2014
45
19 (42.2)
35 (77.7)
16 (35.6)
7 (15.6)
2008–2014
94
38 (40.4)
75 (79.8)
33 (35.1)
14 (14.9)
2
Northwest
Saint Petersburg
Before 2001
18
4 (22.2)
15 (83.3)
3 (16.7)
2 (11.1)
3
Southern
Rostov-on-Don
2008
8
0 (0)
8 (100)
0 (0)
0 (0)
4
Ural
Yekaterinburg
2008
3
1 (33.3)
3 (100)
1 (33.3)
0 (0)
5
Siberian
Novosibirsk
Before 2005
29
6 (20.8)
22 (75.9)
6 (20.7)
7 (23.8)
6
Kyzyl
2008
6
1 (16.7)
4 (66.7)
0 (0)
1 (16.7)
7
Far Eastern
Yakutsk
2008
7
1 (14.3)
6 (85.7)
1 (14.3)
1 (14.3)
8
Khabarovsk
2009
24
8 (33.3)
19 (79.2)
8 (33.3)
5 (20.8)
Intravenous drug users (IDUs); all samples including IDUs.
