Journal of Immunology Research / 2018 / Article / Tab 2

Research Article

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

Table 2

Occurrence of substitutions in amino acid positions 70 and 91 of the nucleocapsid (core) protein of HCV 1b in the samples collected from the general population of the Russian Federation during the routine blood tests.

Number of cohortFederal District of RussiaCityDate of collection of samplesNumber of HCV 1b sequencesMutations found in aa position 70, n (%)Mutations found in aa position 91, n (%)Mutations found in aa positions 70 and 91, n (%)Without mutations in aa positions 70 and 91, n (%)

1CentralMoscow200851 (20.0)4 (80.0)1 (20.0)1 (20.0)
200961 (16.7)5 (83.3)0 (0)0 (0)
20111710 (58.9)15 (88.2)9 (53.0)1 (5.9)
2014217 (33.3)16 (76.2)6 (28.6)4 (19.0)
2008–20144919 (38.7)40 (81.6)17 (34.7)7 (14.2)
20144519 (42.2)35 (77.7)16 (35.6)7 (15.6)
2008–20149438 (40.4)75 (79.8)33 (35.1)14 (14.9)
2NorthwestSaint PetersburgBefore 2001184 (22.2)15 (83.3)3 (16.7)2 (11.1)
3SouthernRostov-on-Don200880 (0)8 (100)0 (0)0 (0)
4UralYekaterinburg200831 (33.3)3 (100)1 (33.3)0 (0)
5SiberianNovosibirskBefore 2005296 (20.8)22 (75.9)6 (20.7)7 (23.8)
6Kyzyl200861 (16.7)4 (66.7)0 (0)1 (16.7)
7Far EasternYakutsk200871 (14.3)6 (85.7)1 (14.3)1 (14.3)
8Khabarovsk2009248 (33.3)19 (79.2)8 (33.3)5 (20.8)

Intravenous drug users (IDUs); all samples including IDUs.