Myokines as Possible Therapeutic Targets in Cancer Cachexia

Figure 1

Effects of myokines in muscle cachexia. The schematic representation of myokine activity in the skeletal muscle shows the following: except for myostatin, which decreases after exercise, all others have a higher level after effort; between myostatin and decorin, there is an antagonistic relationship of mutual inhibition; the arrows show an activation or stimulation relationship between myokines and various metabolic processes that occur in the skeletal muscle.