Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV− Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen

Figure 4

Comparison of fold increases in cytokine-producing and CD107a-expressing memory T cells between study groups. Fold increases in TNF-α, IFN-γ, IL-2, and IL-10 cytokine production, and CD107a expression, by memory CD4+ (a–e) and CD8+ (f–j) T cells in response to recombinant HBsAg between healthy controls (c), the standard dose group (A1), the four doses group (A2), and the four double doses group (A3) were compared before in vivo vaccination on day 0 (D0) and month 7 (7m) after vaccination. Medians are represented by thick, wide horizontal bars; 25–75% interquartile ranges are represented by thin, narrow bars. All values < 0.05 were considered statistically significant. “” stands for .