Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV− Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen

Figure 5

Fold increases in cytokine-producing and CD107a-expressing memory T cells between groups with regard to serological responsiveness to the vaccine. Fold increases in TNF-α, IFN-γ, IL-2, and IL-10 production, and CD107a expression, by memory CD4+ (a) and CD8+ (b) T cells in response to recombinant HBsAg between seronegative (Neg) and seropositive (Pos) individuals among all the HIV+ participants were compared before in vivo vaccination on day 0 (D0) and month 7 (7m) after vaccination. Medians are represented by thick, wide horizontal bars; 25–75% interquartile ranges are represented by thin, narrow bars.