Regulation of Immune Cell Functions by Metabolic Reprogramming

Figure 1

Regulation of metabolic rewiring in macrophages. PGC1 is important for FAO and mitochondrial biogenesis (shown in blue) and HIF1α for aerobic glycolysis (shown in red). Active SIRT1 can inhibit inflammation and glycolytic metabolism and promote mitochondrial biogenesis and FAO. Interaction of PD-L1 and PD-1 induces FAO and suppresses aerobic glycolysis and immune functions in Teff. PD-1: programmed death-1; PD-L1: programmed death ligand-1; RTK: receptor tyrosine kinase; T_EFF: effector T cell.