Regulation of Immune Cell Functions by Metabolic Reprogramming

Figure 3

Metabolic changes in the TME-regulating immune cell function. (a) Lactate produced by cancer cells, as a by-product of aerobic glycolysis, has a critical function in inducing M2-like activation of TAMs. (b) A low-glucose microenvironment via multiple signaling pathways regulates activation state of macrophages and T cells. TCR: T cell receptor; VEGF: vascular endothelial growth factor.

(a)

(b)