CD11c-Specific Deletion Reveals CREB as a Critical Regulator of DC Function during the Germinal Center Response

Figure 2

CREB expression in DCs is not necessary to preserve T-cell homeostasis but alters B cell activation: (a) percentages of CD25⁺Foxp3⁺ cells within CD4⁺ T cells in different lymphoid organs of indicated mice determined by flow cytometry; (b) percentages of CD4⁺ within CD3⁺ T cells in spleens and pLNs of indicated mice determined by flow cytometry; (c) percentages of CD8⁺ within CD3⁺ T cells in spleens and pLNs of indicated mice determined by flow cytometry; (d) percentages of naive (CD62L^high, CD44^low) and memory (CD44^high, CD62L^low) cells within CD4⁺ T cells; (e) percentages of naive (CD62L^high, CD44^low) and memory (CD4^high, CD62L^low) cells within CD8⁺ T cells; (f) percentages of CD19⁺B220⁺ cells in spleen of indicated mice; (g) percentages of GL-7⁺ cells within CD19⁺ cells, unpaired, two-tailed Student’s t-test, ; (h) representative dot plots showing GL-7⁺ cells within B220⁺ population. For (a–g), each dot represents an individual mouse, and horizontal bars indicate SEM. .

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