Effect of CXCR2 Inhibition on Behavioral Outcomes and Pathology in Rat Model of Neuromyelitis Optica

Figure 2

SCH527123 decreases neutrophil migration into the spinal cord of EAE rats with high human IgG levels. (a) In this cohort, Hu-IgG levels were high in both the vehicle- and SCH527123-treated animals. At 30 mg/kg, SCH527123 treatment (red triangles) significantly decreased neutrophil accumulation in the spinal cord of EAE rats when compared to the vehicle-treated group (green circles, ). (b) Examples of His48+neutrophils in the spinal cord of EAE rats (arrows, ). (c) In this cohort, where Human IgG levels in the CNS were more variable, there is a trend towards decreased neutrophil recruitment in SCH527123 treatment at 30 mg/kg compared to vehicle-treated animals only in animals with high Hu-IgG scores, but high variability in the vehicle-treated group limits the differences between these groups (Student’s t-test ; variance is significantly increased ). (d) Pooling results for rats with high IgG in their spinal cords from the two cohorts for vehicle and SCH527123 treatment at 30 mg/kg indicate that this higher dose significantly decreases His48+neutrophil recruitment following high levels of human IgG deposition in the spinal cord of EAE rats ().

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