Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis
Table 2
The table shows the transcripts that differed by >2.0 fold with in inflamed mucosa (IM) vs. noninflamed mucosa (NM) in UC and CD patients. Genes are arranged by alphabetic order. Italic fonts indicate genes differentially expressed only in IM from UC.
Gene
Description
UC
CD
Paired IM vs. NM
Paired IM vs. NM
FC
value
FC
value
C3
Complement C3
5.48
0.0106
C4BPB
Complement component 4 binding protein beta
5.86
<0.0001
2.98
0.0090
CCL11
C-C motif chemokine ligand 11
2.01
0.0121
2.27
0.0045
CCL20
C-C motif chemokine ligand 20
4.05
0.0003
CD55
CD55 molecule (Cromer blood group)
3.63
<0.0001
CHI3L1
Chitinase 3 like 1
16.96
0.0045
4.19
0.0328
CR2
Complement C3d receptor 2
7.00
0.0150
CXCL1
C-X-C motif chemokine ligand 1
17.99
<0.0001
6.82
0.0413
CXCL10
C-X-C motif chemokine ligand 10
3.23
0.0008
CXCL11
C-X-C motif chemokine ligand 11
8.93
0.0001
4.32
0.0380
CXCL2
C-X-C motif chemokine ligand 2
14.98
<0.0001
CXCL3
C-X-C motif chemokine ligand 3
9.79
<0.0001
CXCL9
C-X-C motif chemokine ligand 9
5.16
0.0002
5.22
0.0059
CXCR1
C-X-C motif chemokine receptor 1
19.22
0.0131
EDN3
Endothelin 3
−2.92
0.0048
FPR1
Formyl peptide receptor 1
10.57
0.0035
IFNG
Interferon gamma
2.82
<0.0001
IL1RN
Interleukin 1 receptor antagonist
8.15
0.0018
5.68
0.0498
IL23A
Interleukin 23 subunit alpha
3.11
<0.0001
IL2RA
Interleukin 2 receptor subunit alpha
3.45
0.0006
CXCL8
C-X-C motif chemokine ligand 8
19.40
0.0185
ITGB2
Integrin subunit beta 2
2.31
0.0003
LCN2
Lipocalin 2
13.05
0.0003
LTB
Lymphotoxin beta
4.01
0.0007
LYZ
Lysozyme
2.06
0.0009
2.16
0.0344
MMP1
Matrix metallopeptidase 1
9.98
0.0108
MMP10
Matrix metallopeptidase 10
14.92
0.0004
MMP3
Matrix metallopeptidase 3
30.01
0.0016
MMP7
Matrix metallopeptidase 7
37.37
0.0036
6.00
0.0098
NOS2
Nitric oxide synthase 2
10.99
0.0005
PCK1
Phosphoenolpyruvate carboxykinase 1
−6.29
0.0002
PECAM1
Platelet endothelial cell adhesion molecule 1
2.42
0.0046
REG1A
Regenerating family member 1 alpha
10.11
0.0123
S100A8
S100 calcium binding protein A8
17.91
0.0018
S100A9
S100 calcium binding protein A9
9.31
0.0005
SAA1
Serum amyloid A1
62.83
0.0016
SELL
Selectin L
5.31
<0.0001
SOD2
Superoxide dismutase 2
2.14
0.0003
2.03
0.0429
STAT1
Signal transducer and activator of transcription 1
