Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis

Table 3

The table shows the transcripts that differed by >2.0 fold with in inflamed mucosa (IM) and noninflamed mucosa (NM) of UC and CD patients compared with healthy controls. Genes are arranged by alphabetic order. Italic fonts indicate genes differentially expressed both in NM and IM compared to controls.

Gene	Description	UC				CD
		IM () vs. C ()		NM () vs. C ()		IM () vs. C ()		NM () vs. C ()
		FC	value	FC	value	FC	value	FC	value
ABCB1	ATP binding cassette subfamily B member 1	−7.04	0.0158			−3.76	0.0417
ALDOB	Aldolase, fructose-bisphosphate B	−18.72	0.0269
C3	Complement C3	3.77	0.0264
C4BPB	Complement component 4 binding protein beta	10.05	<0.0001			8.21	<0.0001	2.76	0.0310
CCL11	C-C motif chemokine ligand 11	3.99	0.0003	2.056	0.003	3.90	<0.0001
CCL2	C-C motif chemokine ligand 2	2.58	0.0413
CCL20	C-C motif chemokine ligand 20	3.36	0.0009
CCL25	C-C motif chemokine ligand 25	−13.47	0.0403
CCR9	C-C motif chemokine receptor 9	−2.89	0.0179
CD55	CD55 molecule (Cromer blood group)	4.63	<0.0001			2.80	0.0006
CHI3L1	Chitinase 3 like 1	42.55	0.0016			39.26	0.0049
CSTA	Cystatin A	2.64	0.0045
CXCL1	C-X-C motif chemokine ligand 1	12.34	<0.0001			12.60	0.0240
CXCL10	C-X-C motif chemokine ligand 10	2.85	0.0013			9.36	0.0416
CXCL11	C-X-C motif chemokine ligand 11	7.28	0.0003			12.59	0.0077
CXCL2	C-X-C motif chemokine ligand 2	9.16	<0.0001			10.09	0.0368
CXCL3	C-X-C motif chemokine ligand 3	7.17	<0.0001			5.74	0.0123
CXCL9	C-X-C motif chemokine ligand 9	5.36	<0.0001			11.04	0.0016
CXCR1	C-X-C motif chemokine receptor 1	50.54	0.0103			53.31	0.0152
DEFA5	Defensin alpha 5	−11.68	0.0422
DEFA6	Defensin alpha 6	−12.36	0.0368
FPR1	Formyl peptide receptor 1	11.09	0.0031
IFNG	Interferon gamma	2.89	0.0001			3.11	0.0287
IL13	Interleukin 13	4.08	0.0046			2.82	0.0083
IL17A	Interleukin 17A	4.31	0.0032			2.39	0.0048
IL1RN	Interleukin 1 receptor antagonist	12.45	0.0011			14.78	0.0233	2.6	0.0233
IL23A	Interleukin 23 subunit alpha	3.26	0.0013
IL2RA	Interleukin 2 receptor subunit alpha	2.61	0.0026			2.44	0.0073
CXCL8	C-X-C motif chemokine ligand 8	24.75	0.0169
ITGB2	Integrin subunit beta 2	2.32	0.0005			1.75	0.0126
LCN2	Lipocalin 2	19.25	0.0002			13.56	0.0006	5.957	0.0074
LTB	Lymphotoxin beta	2.91	0.0061
MMP1	Matrix metallopeptidase 1	16.79	0.0074
MMP10	Matrix metallopeptidase 10	53.71	0.0002	3.6	0.0085	22.84	<0.0001
MMP3	Matrix metallopeptidase 3	52.13	0.0013
MMP7	Matrix metallopeptidase 7	286.33	0.0027			87.38	0.0030
MUC1	Mucin 1, cell surface associated	2.65	<0.0001			2.79	0.0017	2.14	0.0024
NOS2	Nitric oxide synthase 2	11.93	0.0006			7.09	<0.0001
PCK1	Phosphoenolpyruvate carboxykinase 1	−6.49	<0.0001			−2.36	0.0077
PECAM1	Platelet and endothelial cell adhesion molecule 1	3.09	0.0021			2.57	0.0060
S100A8	S100 calcium binding protein A8	28.57	0.0014
S100A9	S100 calcium binding protein A9	16.56	0.0002			33.97	0.0364	3.61	0.0257
SELL	Selectin L	3.87	0.0003			3.97	0.0418
SOD2	Superoxide dismutase 2	2.17	0.0005			2.33	0.0166
TDO2	Tryptophan 2,3-dioxygenase	3.88	<0.0001
TFF1	Trefoil factor 1	3.06	0.0001			2.91	0.0440
TIMP1	TIMP metallopeptidase inhibitor 1	6.12	<0.0001			4.21	0.0011
UBD	Ubiquitin D	5.19	0.0006			4.99	0.0007
VWF	Von Willebrand factor	3.17	<0.0001			2.84	0.0022