Journal of Immunology Research / 2018 / Article / Tab 2

Research Article

Immune Response to Rotavirus and Gluten Sensitivity

Table 2

Genes modulated in NCGS patients that are involved in immune response and molecular signalings.

Probe set ID valueGene symbolGene titleFCRepresentative public ID

T cell activation
203809_s_at<0.001AKT2v-akt murine thymoma viral oncogene homolog 22.36NM_001626
211861_x_at<0.001CD28CD28 molecule2.75AF222343
205456_at<0.001CD3ECD3e molecule, epsilon (CD3-TCR complex)2.67NM_000733
206804_at<0.001CD3GCD3g molecule, gamma (CD3-TCR complex)2.13NM_000073
211027_s_at<0.001IKBKBInhibitor of kappa light polyp. gene enhancer in B cells, kinase β2.69NM_001190720
213281_at0.007JUNjun proto-oncogene3.07NM_002228.3
204890_s_at<0.001LCKLymphocyte-specific protein tyrosine kinase2.05U07236
213490_s_at<0.001MAP2K2Mitogen-activated protein kinase kinase 21.83NM_030662
214786_at0.013MAP3K1Mitogen-activated protein kinase kinase kinase 11.52NM_005921
210671_x_at<0.001MAPK8Mitogen-activated protein kinase 82.33NM_001278548
211230_s_at<0.001PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic sub. Δ1.88U57843
212249_at0.002PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)2.76NM_181523
216551_x_at0.001PLCG1Phospholipase C, gamma 11.53NM_002660
208640_at<0.001RAC1Rho family, small GTP-binding protein Rac1−1.92NM_006908
207419_s_at<0.001RAC2Rho family, small GTP-binding protein Rac22.31NM_002872
217576_x_at0.002SOS2Son of sevenless homolog 21.90NM_006939
216042_at<0.001TNFRSF25Tumor necrosis factor receptor superfamily, member 252.40NM_148965
221331_x_at<0.001CTLA4Cytotoxic T-lymphocyte-associated protein 42.26NM_005214
206569_at<0.001IL24Interleukin 242.84NM_006850
203828_s_at0.003IL32Interleukin 322.10NM_004221
B cell mediated immune response
211027_s_at<0.001IKBKBInhibitor of kappa light polyp. gene enhancer in B cells, kinase β2.69NM_001190720
213281_at0.007JUNjun proto-oncogene3.07NM_002228.3
202626_s_at0.004LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog−2.22AI356412
213490_s_at<0.001MAP2K2Mitogen-activated protein kinase kinase 21.83NM_030662
210671_x_at<0.001MAPK8Mitogen-activated protein kinase 82.33NM_001278548
211230_s_at<0.001PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic sub. Δ1.88U57843
32540_at<0.001PPP3CCProtein phosphatase 3, catalytic subunit, gamma isozyme2.00NM_001243975
208640_at<0.001RAC1Rho family, small GTP-binding protein Rac1−1.92NM_006908
207419_s_at<0.001RAC2Family, small GTP-binding protein Rac22.31NM_002872
217576_x_at0.002SOS2Son of sevenless homolog 21.90NM_006939
207540_s_at0.008SYKSpleen tyrosine kinase−1.92NM_003177
207224_s_at0.003SIGLEC7Sialic acid-binding Ig-like lectin 7−2.21NM_016543
206150_at0.004CD27CD27 molecule1.96NM_001242
214447_at0.005ETS1v-ets erythroblastosis virus E26 oncogene homolog 12.25NM_005238
201328_at0.012ETS2v-ets erythroblastosis virus E26 oncogene homolog 2−1.83NM_005239
212420_at0.001ELF1E74-like factor 1 (ets domain transcription factor)1.94KJ896761
211825_s_at<0.001FLI1Friend leukemia virus integration 12.28AF327066
215967_s_at<0.001LY9Lymphocyte antigen 92.08NM_002348
210690_at0.001KLRC4Killer cell lectin-like receptor subfamily C, member 42.23U96845
204116_at<0.001IL2RGInterleukin 2 receptor, gamma1.84NM_000206
217489_s_at<0.001IL6RInterleukin 6 receptor1.79S72848
204863_s_at<0.001IL6STInterleukin 6 signal transducer (gp130, oncostatin M receptor)4.52NM_002184
206966_s_at<0.001KLF12Kruppel-like factor 121.83AH010423
219878_s_at<0.001KLF13Kruppel-like factor 131.89NM_015995
219386_s_at<0.001SLAMF8SLAM family member 8−2.27NM_020125
210405_x_at0.003TNFRSF10BTumor necrosis factor receptor superfamily, member 10b1.50NM_003842
219386_s_at<0.001SLAMF8SLAM family member 8−2.27NM_020125
210405_x_at0.003TNFRSF10BTumor necrosis factor receptor superfamily, member 10b1.50NM_003842
203508_at0.005TNFRSF1BTumor necrosis factor receptor superfamily, member 1B−2.06NM_001066
216042_at<0.001TNFRSF25Tumor necrosis factor receptor superfamily, member 252.40NM_148965
218856_at0.008TNFRSF21Tumor necrosis factor receptor superfamily, member 21−1.68NM_014452
206181_at0.003SLAMF1Signaling lymphocytic activation molecule family member 11.65NM_003037
210796_x_at<0.001SIGLEC6Sialic acid-binding Ig-like lectin 61.58D86359
211192_s_at<0.001CD84CD84 molecule2.55AF054818
220132_s_at<0.001CLEC2DC-type lectin domain family 2, member D3.18NM_013269
204773_at0.005IL11RAInterleukin 11 receptor, alpha1.56AY532110
210850_s_at<0.001ELK1ELK1, member of ETS oncogene family1.60AF000672
209894_at0.002LEPRLeptin receptor−2.10U50748
203005_at0.006LTBRLymphotoxin beta receptor (TNFR superfamily, member 3)−1.92NM_002342
NK cell activation
220132_s_at<0.001CLEC2DC-type lectin domain family 2, member D3.18NM_013269
203233_at0.014IL4RInterleukin 4 receptor1.50NM_000418
210152_at0.007LILRB4Leukocyte immunoglobulin-like receptor, subfamily B, member 4−1.83NM_001278426
210784_x_at0.012LILRA6Leukocyte immunoglobulin-like receptor, subfamily A, member 6−1.74NM_024318
211405_x_at0.003IFNA17Interferon, alpha 171.59NM_021268
210660_at0.008LILRA1Leukocyte immunoglobulin-like receptor, subfamily A, member 1−2.81NM_001278319
207857_at0.016LILRA2Leukocyte immunoglobulin-like receptor, subfamily A, member 2−2.35NM_006866
210690_at0.001KLRC4Killer cell lectin-like receptor subfamily C, member 42.23U96845
206881_s_at0.013LILRA3Leukocyte immunoglobulin-like receptor, subfamily A, member 3−2.96NM_006865
210313_at0.003LILRA4Leukocyte immunoglobulin-like receptor, subfamily A, member 4−1.83NM_012276
215838_at0.012LILRA5Leukocyte immunoglobulin-like receptor, subfamily A, member 5−3.15NM_181985
210146_x_at0.004LILRB2Leukocyte immunoglobulin-like receptor, subfamily B, member 2−3.41AF004231
208982_at0.008PECAM1Platelet/endothelial cell adhesion molecule 1−1.73M37780
203828_s_at0.003IL32Interleukin 322.10NM_004221
Macrophage activation
210405_x_at0.003TNFRSF10BTumor necrosis factor receptor superfamily, member 10b1.50NM_003842
221900_at0.003COL8A2Collagen, type VIII, alpha 2−1.62NM_005202
205819_at<0.001MARCOMacrophage receptor with collagenous structure−3.01NM_006770
208602_x_at<0.001CD6CD6 molecule3.67NM_006725
207540_s_at0.008SYKSpleen tyrosine kinase−1.92NM_003177
203508_at0.005TNFRSF1BTumor necrosis factor receptor superfamily, member 1B−2.06NM_001066
204438_at0.012MRC1Mannose receptor, C type 1−2.04NM_002438
202269_x_at0.006GBP1Guanylate binding protein 1, interferon-inducible−1.77NM_002053
208982_at0.008PECAM1Platelet/endothelial cell adhesion molecule 1−1.73M37780
Complement activation
205500_at0.006C5Complement component 5−1.60NM_001735
206244_at0.003CR1Complement component (3b/4b) receptor 1 (Knops blood group)−1.79NM_000573
Response to gamma interferon
205831_at0.001CD2CD2 molecule2.00NM_001767
205468_s_at0.015IRF5Interferon regulatory factor 51.52NM_032643
219386_s_at<0.001SLAMF8SLAM family member 8−2.27NM_020125
211192_s_at<0.001CD84CD84 molecule2.55AF054818
202269_x_at0.006GBP1Guanylate-binding protein 1, interferon-inducible−1.77NM_002053
202621_at<0.001IRF3Interferon regulatory factor 31.67NM_001571
33148_at<0.001ZFRZinc finger RNA binding protein2.19NM_016107
206181_at0.003SLAMF1Signaling lymphocytic activation molecule family member 11.65NM_003037
215967_s_at<0.001LY9Lymphocyte antigen 92.08NM_002348
201461_s_at0.011MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 21.85NM_004759
216450_x_at<0.001HSP90B1Heat shock protein 90 kDa beta (Grp94), member 13.76AK025862
214370_at<0.001S100A8S100 calcium-binding protein A83.65AW238654
Antigen processing and presentation
206050_s_at0.010RNH1Ribonuclease/angiogenin inhibitor 1−1.53NM_002939
204770_at<0.001TAP2Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)1.86NM_000544
TH17 related genes
203233_at0.014IL4RInterleukin 4 receptor1.50NM_000418
204116_at<0.001IL2RGInterleukin 2 receptor, gamma1.84NM_000206
204863_s_at<0.001IL6STInterleukin 6 signal transducer (gp130, oncostatin M receptor)4.52NM_002184
205067_at0.015IL1BInterleukin 1, beta1.52NM_000576
205798_at0.011IL7RInterleukin 7 receptor1.55NM_002185
201332_s_at0.013STAT6Signal transducer and activator of transcription 61.54AH006951
205026_at<0.001STAT5BSignal transducer and activator of transcription 5B1.60NM_012448
206360_s_at<0.001SOCS3Suppressor of cytokine signaling 31.83NM_003955
209774_x_at0.015CXCL2Chemokine (C-X-C motif) ligand 21.53M57731
Type I interferon signaling
211405_x_at0.003IFNA17Interferon, alpha 171.59NM_021268
205468_s_at0.015IRF5Interferon regulatory factor 51.52NM_032643
202621_at<0.001IRF3Interferon regulatory factor 31.67NM_001571
217199_s_at<0.001STAT2Signal transducer and activator of transcription 2, 113 kDa1.59S81491
M97935_5_at<0.001STAT1Signal transducer and activator of transcription 1, 91 kDa2.73NM_007315
210370_s_at<0.001LY9Lymphocyte antigen 92.05NM_002348