Immune Response to Rotavirus and Gluten Sensitivity

Table 2

Genes modulated in NCGS patients that are involved in immune response and molecular signalings.

Probe set ID	value	Gene symbol	Gene title	FC	Representative public ID
T cell activation
203809_s_at	<0.001	AKT2	v-akt murine thymoma viral oncogene homolog 2	2.36	NM_001626
211861_x_at	<0.001	CD28	CD28 molecule	2.75	AF222343
205456_at	<0.001	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	2.67	NM_000733
206804_at	<0.001	CD3G	CD3g molecule, gamma (CD3-TCR complex)	2.13	NM_000073
211027_s_at	<0.001	IKBKB	Inhibitor of kappa light polyp. gene enhancer in B cells, kinase β	2.69	NM_001190720
213281_at	0.007	JUN	jun proto-oncogene	3.07	NM_002228.3
204890_s_at	<0.001	LCK	Lymphocyte-specific protein tyrosine kinase	2.05	U07236
213490_s_at	<0.001	MAP2K2	Mitogen-activated protein kinase kinase 2	1.83	NM_030662
214786_at	0.013	MAP3K1	Mitogen-activated protein kinase kinase kinase 1	1.52	NM_005921
210671_x_at	<0.001	MAPK8	Mitogen-activated protein kinase 8	2.33	NM_001278548
211230_s_at	<0.001	PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic sub. Δ	1.88	U57843
212249_at	0.002	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	2.76	NM_181523
216551_x_at	0.001	PLCG1	Phospholipase C, gamma 1	1.53	NM_002660
208640_at	<0.001	RAC1	Rho family, small GTP-binding protein Rac1	−1.92	NM_006908
207419_s_at	<0.001	RAC2	Rho family, small GTP-binding protein Rac2	2.31	NM_002872
217576_x_at	0.002	SOS2	Son of sevenless homolog 2	1.90	NM_006939
216042_at	<0.001	TNFRSF25	Tumor necrosis factor receptor superfamily, member 25	2.40	NM_148965
221331_x_at	<0.001	CTLA4	Cytotoxic T-lymphocyte-associated protein 4	2.26	NM_005214
206569_at	<0.001	IL24	Interleukin 24	2.84	NM_006850
203828_s_at	0.003	IL32	Interleukin 32	2.10	NM_004221
B cell mediated immune response
211027_s_at	<0.001	IKBKB	Inhibitor of kappa light polyp. gene enhancer in B cells, kinase β	2.69	NM_001190720
213281_at	0.007	JUN	jun proto-oncogene	3.07	NM_002228.3
202626_s_at	0.004	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	−2.22	AI356412
213490_s_at	<0.001	MAP2K2	Mitogen-activated protein kinase kinase 2	1.83	NM_030662
210671_x_at	<0.001	MAPK8	Mitogen-activated protein kinase 8	2.33	NM_001278548
211230_s_at	<0.001	PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic sub. Δ	1.88	U57843
32540_at	<0.001	PPP3CC	Protein phosphatase 3, catalytic subunit, gamma isozyme	2.00	NM_001243975
208640_at	<0.001	RAC1	Rho family, small GTP-binding protein Rac1	−1.92	NM_006908
207419_s_at	<0.001	RAC2	Family, small GTP-binding protein Rac2	2.31	NM_002872
217576_x_at	0.002	SOS2	Son of sevenless homolog 2	1.90	NM_006939
207540_s_at	0.008	SYK	Spleen tyrosine kinase	−1.92	NM_003177
207224_s_at	0.003	SIGLEC7	Sialic acid-binding Ig-like lectin 7	−2.21	NM_016543
206150_at	0.004	CD27	CD27 molecule	1.96	NM_001242
214447_at	0.005	ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1	2.25	NM_005238
201328_at	0.012	ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2	−1.83	NM_005239
212420_at	0.001	ELF1	E74-like factor 1 (ets domain transcription factor)	1.94	KJ896761
211825_s_at	<0.001	FLI1	Friend leukemia virus integration 1	2.28	AF327066
215967_s_at	<0.001	LY9	Lymphocyte antigen 9	2.08	NM_002348
210690_at	0.001	KLRC4	Killer cell lectin-like receptor subfamily C, member 4	2.23	U96845
204116_at	<0.001	IL2RG	Interleukin 2 receptor, gamma	1.84	NM_000206
217489_s_at	<0.001	IL6R	Interleukin 6 receptor	1.79	S72848
204863_s_at	<0.001	IL6ST	Interleukin 6 signal transducer (gp130, oncostatin M receptor)	4.52	NM_002184
206966_s_at	<0.001	KLF12	Kruppel-like factor 12	1.83	AH010423
219878_s_at	<0.001	KLF13	Kruppel-like factor 13	1.89	NM_015995
219386_s_at	<0.001	SLAMF8	SLAM family member 8	−2.27	NM_020125
210405_x_at	0.003	TNFRSF10B	Tumor necrosis factor receptor superfamily, member 10b	1.50	NM_003842
219386_s_at	<0.001	SLAMF8	SLAM family member 8	−2.27	NM_020125
210405_x_at	0.003	TNFRSF10B	Tumor necrosis factor receptor superfamily, member 10b	1.50	NM_003842
203508_at	0.005	TNFRSF1B	Tumor necrosis factor receptor superfamily, member 1B	−2.06	NM_001066
216042_at	<0.001	TNFRSF25	Tumor necrosis factor receptor superfamily, member 25	2.40	NM_148965
218856_at	0.008	TNFRSF21	Tumor necrosis factor receptor superfamily, member 21	−1.68	NM_014452
206181_at	0.003	SLAMF1	Signaling lymphocytic activation molecule family member 1	1.65	NM_003037
210796_x_at	<0.001	SIGLEC6	Sialic acid-binding Ig-like lectin 6	1.58	D86359
211192_s_at	<0.001	CD84	CD84 molecule	2.55	AF054818
220132_s_at	<0.001	CLEC2D	C-type lectin domain family 2, member D	3.18	NM_013269
204773_at	0.005	IL11RA	Interleukin 11 receptor, alpha	1.56	AY532110
210850_s_at	<0.001	ELK1	ELK1, member of ETS oncogene family	1.60	AF000672
209894_at	0.002	LEPR	Leptin receptor	−2.10	U50748
203005_at	0.006	LTBR	Lymphotoxin beta receptor (TNFR superfamily, member 3)	−1.92	NM_002342
NK cell activation
220132_s_at	<0.001	CLEC2D	C-type lectin domain family 2, member D	3.18	NM_013269
203233_at	0.014	IL4R	Interleukin 4 receptor	1.50	NM_000418
210152_at	0.007	LILRB4	Leukocyte immunoglobulin-like receptor, subfamily B, member 4	−1.83	NM_001278426
210784_x_at	0.012	LILRA6	Leukocyte immunoglobulin-like receptor, subfamily A, member 6	−1.74	NM_024318
211405_x_at	0.003	IFNA17	Interferon, alpha 17	1.59	NM_021268
210660_at	0.008	LILRA1	Leukocyte immunoglobulin-like receptor, subfamily A, member 1	−2.81	NM_001278319
207857_at	0.016	LILRA2	Leukocyte immunoglobulin-like receptor, subfamily A, member 2	−2.35	NM_006866
210690_at	0.001	KLRC4	Killer cell lectin-like receptor subfamily C, member 4	2.23	U96845
206881_s_at	0.013	LILRA3	Leukocyte immunoglobulin-like receptor, subfamily A, member 3	−2.96	NM_006865
210313_at	0.003	LILRA4	Leukocyte immunoglobulin-like receptor, subfamily A, member 4	−1.83	NM_012276
215838_at	0.012	LILRA5	Leukocyte immunoglobulin-like receptor, subfamily A, member 5	−3.15	NM_181985
210146_x_at	0.004	LILRB2	Leukocyte immunoglobulin-like receptor, subfamily B, member 2	−3.41	AF004231
208982_at	0.008	PECAM1	Platelet/endothelial cell adhesion molecule 1	−1.73	M37780
203828_s_at	0.003	IL32	Interleukin 32	2.10	NM_004221
Macrophage activation
210405_x_at	0.003	TNFRSF10B	Tumor necrosis factor receptor superfamily, member 10b	1.50	NM_003842
221900_at	0.003	COL8A2	Collagen, type VIII, alpha 2	−1.62	NM_005202
205819_at	<0.001	MARCO	Macrophage receptor with collagenous structure	−3.01	NM_006770
208602_x_at	<0.001	CD6	CD6 molecule	3.67	NM_006725
207540_s_at	0.008	SYK	Spleen tyrosine kinase	−1.92	NM_003177
203508_at	0.005	TNFRSF1B	Tumor necrosis factor receptor superfamily, member 1B	−2.06	NM_001066
204438_at	0.012	MRC1	Mannose receptor, C type 1	−2.04	NM_002438
202269_x_at	0.006	GBP1	Guanylate binding protein 1, interferon-inducible	−1.77	NM_002053
208982_at	0.008	PECAM1	Platelet/endothelial cell adhesion molecule 1	−1.73	M37780
Complement activation
205500_at	0.006	C5	Complement component 5	−1.60	NM_001735
206244_at	0.003	CR1	Complement component (3b/4b) receptor 1 (Knops blood group)	−1.79	NM_000573
Response to gamma interferon
205831_at	0.001	CD2	CD2 molecule	2.00	NM_001767
205468_s_at	0.015	IRF5	Interferon regulatory factor 5	1.52	NM_032643
219386_s_at	<0.001	SLAMF8	SLAM family member 8	−2.27	NM_020125
211192_s_at	<0.001	CD84	CD84 molecule	2.55	AF054818
202269_x_at	0.006	GBP1	Guanylate-binding protein 1, interferon-inducible	−1.77	NM_002053
202621_at	<0.001	IRF3	Interferon regulatory factor 3	1.67	NM_001571
33148_at	<0.001	ZFR	Zinc finger RNA binding protein	2.19	NM_016107
206181_at	0.003	SLAMF1	Signaling lymphocytic activation molecule family member 1	1.65	NM_003037
215967_s_at	<0.001	LY9	Lymphocyte antigen 9	2.08	NM_002348
201461_s_at	0.011	MAPKAPK2	Mitogen-activated protein kinase-activated protein kinase 2	1.85	NM_004759
216450_x_at	<0.001	HSP90B1	Heat shock protein 90 kDa beta (Grp94), member 1	3.76	AK025862
214370_at	<0.001	S100A8	S100 calcium-binding protein A8	3.65	AW238654
Antigen processing and presentation
206050_s_at	0.010	RNH1	Ribonuclease/angiogenin inhibitor 1	−1.53	NM_002939
204770_at	<0.001	TAP2	Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	1.86	NM_000544
TH17 related genes
203233_at	0.014	IL4R	Interleukin 4 receptor	1.50	NM_000418
204116_at	<0.001	IL2RG	Interleukin 2 receptor, gamma	1.84	NM_000206
204863_s_at	<0.001	IL6ST	Interleukin 6 signal transducer (gp130, oncostatin M receptor)	4.52	NM_002184
205067_at	0.015	IL1B	Interleukin 1, beta	1.52	NM_000576
205798_at	0.011	IL7R	Interleukin 7 receptor	1.55	NM_002185
201332_s_at	0.013	STAT6	Signal transducer and activator of transcription 6	1.54	AH006951
205026_at	<0.001	STAT5B	Signal transducer and activator of transcription 5B	1.60	NM_012448
206360_s_at	<0.001	SOCS3	Suppressor of cytokine signaling 3	1.83	NM_003955
209774_x_at	0.015	CXCL2	Chemokine (C-X-C motif) ligand 2	1.53	M57731
Type I interferon signaling
211405_x_at	0.003	IFNA17	Interferon, alpha 17	1.59	NM_021268
205468_s_at	0.015	IRF5	Interferon regulatory factor 5	1.52	NM_032643
202621_at	<0.001	IRF3	Interferon regulatory factor 3	1.67	NM_001571
217199_s_at	<0.001	STAT2	Signal transducer and activator of transcription 2, 113 kDa	1.59	S81491
M97935_5_at	<0.001	STAT1	Signal transducer and activator of transcription 1, 91 kDa	2.73	NM_007315
210370_s_at	<0.001	LY9	Lymphocyte antigen 9	2.05	NM_002348