Journal of Immunology Research / 2018 / Article / Tab 7

Research Article

Immune Response to Rotavirus and Gluten Sensitivity

Table 7

Selection of genes modulated in PBCs in course of the acute phase of rotavirus infection, involved in immune response and in molecular signaling related to the viral infection process.

Gene symbolGene titleFC

Immune response
ADGRE3Adhesion G protein-coupled receptor E3;ADGRE3;ortholog−3.35
ADIPOQAdiponectin, C1Q and collagen domain containing−1.60
BLKBLK proto-oncogene, Src family tyrosine kinase1.72
BRAFB-Raf proto-oncogene, serine/threonine kinase1.57
BTKBruton agammaglobulinemia tyrosine kinase−1.59
C1QTNF9C1q and tumor necrosis factor related protein 9−1.69
CD109CD109 molecule−1.84
CD79BCD79b molecule, immunoglobulin-associated beta−1.67
CLEC7AC-type lectin domain family 7, member A−1.62
CMIPc-Maf inducing protein−3.50
CSF2RAColony-stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)−2.30
CXCL2Chemokine (C-X-C motif) ligand 2−3.76
CXCL8Chemokine (C-X-C motif) ligand 8−8.65
FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptide−5.64
HCSTHematopoietic cell signal transducer1.85
IL18BPInterleukin 18 binding protein1.56
JAG1Jagged 1−2.06
KLRB1Killer cell lectin-like receptor subfamily B, member 1−5.99
MAP3K11Mitogen-activated protein kinase kinase kinase 111.55
MASP1Mannan-binding lectin serine peptidase 1−1.50
MR1Major histocompatibility complex, class I-related8.43
PLEKHN1Pleckstrin homology domain containing, family N member 1−1.99
PPP2R2CProtein phosphatase 2, regulatory subunit B, gamma−1.84
PPP3CAProtein phosphatase 3, catalytic subunit, alpha isozyme−1.89
PSME3Proteasome activator subunit 31.91
PVRPoliovirus receptor−1.59
STAT5BSignal transducer and activator of transcription 5B−2.06
TNFRSF10CTumor necrosis factor receptor superfamily, member 10c decoy without an intracellular domain−1.75
TNFRSF4Tumor necrosis factor receptor superfamily, member 41.94
Type I interferon signaling
Positive regulation of Type I interferon production
 EP300E1A-binding protein p300−1.56
 POLR3GPolymerase (RNA) III (DNA directed) polypeptide G (32kD)−1.98
 CREBBPCREB-binding protein−1.83
 LRRFIP1Leucine rich repeat (in FLII) interacting protein 1−2.14
 SOCS1Suppressor of cytokine signaling 12.32
Negative regulation of Type I interferon production
 UBBUbiquitin B1.75
 ITCHItchy E3 ubiquitin protein ligase2.26
 TAX1BP1Tax1 (human T cell leukemia virus type I) binding protein 1−4.01
Negative regulation of Type I interferon pathway
 PTPN2Protein tyrosine phosphatase, nonreceptor type 22.10
Positive regulation of interferon beta production
 ZBTB20Zinc finger and BTB domain containing 204.27
Negative regulation of interferon Beta production
 PTPRSProtein tyrosine phosphatase, receptor type, S−2.00
 CACTINCactin, spliceosome C complex subunit−2.53
Cellular response to interferon alpha
 TPRTranslocated promoter region, nuclear basket protein−2.55
Negative regulation of interferon alpha production
 PTPRSProtein tyrosine phosphatase, receptor type, S−2.00
Type I interferon signaling pathway
 JAK1Janus kinase 11.79
 IFI27Interferon, alpha-inducible protein 2775.26
 IFI27L2Interferon, alpha-inducible protein 27-like 2−1.59
 IKBKEInhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon1.50
 TPRTranslocated promoter region, nuclear basket protein−2.55
Positive regulation of Type I interferon pathway
 MMEMembrane metallo-endopeptidase−5.54
Gamma interferon signaling
JAK1Janus kinase 11.79
HLADQB1Major histocompatibility complex, class II, DQ beta 1−36.43
HLADQA1Major histocompatibility complex, class II, DQ alpha 1−37.95
PIAS3Protein inhibitor of activated STAT 32.11
HLADRB1Major histocompatibility complex, class II, DR beta 1−10.91
MAPK8Mitogen-activated protein kinase 8−2.28
MAPK1Mitogen-activated protein kinase 1−2.23
Regulation of interferon gamma signaling pathway
 PTPN2Protein tyrosine phosphatase, nonreceptor type 22.10
Positive regulation of interferon gamma production
 PDE4BPhosphodiesterase 4B, cAMP-specific−1.77
 ZFPM1Zinc finger protein, FOG family member 11.75
Negative regulation of interferon gamma production
 HLADRB1Major histocompatibility complex, class II, DR beta 1−10.91
 RARARetinoic acid receptor, alpha−7.60
 FOXP3Forkhead box P3−2.14
Cellular response to interferon gamma
 SLC26A6Solute carrier family 26 (anion exchanger), member 61.95
 DAPK3Death-associated protein kinase 3−1.62
 CD40CD40 molecule, TNF receptor superfamily member 52.72
 MEFVMediterranean fever−4.83
 SNCASynuclein alpha8.62
 MRC1Mannose receptor, C type 1−1.93
Toll-like receptors signaling pathway
TANKTRAF family member-associated NFKB activator−1.91
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha−1.76
MAPK8Mitogen-activated protein kinase 8−2.28
IKBKEInhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon1.50
MAPK1Mitogen-activated protein kinase 1−2.23
JUNjun proto-oncogene−1.91