Research Article

A Dual-Type L2 11-88 Peptide from HPV Types 16/18 Formulated in Montanide ISA 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated with High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice

Table 1

Group of mice immunized with different dual-type L2 peptides formulated in CFA/IFA.

GroupsImmunogen

G1(HPV 16) 17-36 × 3 + (HPV 18) 17-36 × 3 in CFA/IFA
G2(HPV 16) 69-81 × 3 + (HPV 18) 69-81 × 3 in CFA/IFA
G3(HPV 16) 11-88 × 1 + (HPV 18) 11-88 × 1 in CFA/IFA
G4 (control group)CFA/IFA
G5 (control group)PBS

CFA and IFA denote the complete and incomplete Freund adjuvants, respectively. CFA was used for formulation of the immunogen in first immunization and IFA for next immunizations. Control groups are deprived from antigen.