PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins
Table 2
Univariate and multivariate analyses for prognostic factors affecting OS in CRC.
Risk factors
Univariate analysis
Risk factors
Multivariate analysis
HR (95% CI)
HR (95% CI)
Menopause status: menopause
2.437 (0.879–6.756)
0.087
Menopause status: menopause
3.381 (1.062–10.759)
0.039
Ratio of signet cells: high
4.655 (1.366–15.863)
0.014
Ratio of signet cells: high
2.301 (0.613–8.641)
0.217
Tumor PD-L1 expression: negative
5.129 (1.567–16.791)
0.007
Tumor PD-L1 expression: negative
4.451 (1.062–18.658)
0.041
Ovarian involvement: bilateral
1.155 (0.429–3.109)
0.776
CD8+ cell density: low
1.816 (0.462–7.140)
0.393
CD3+ cell density: low
1.640 (0.606–4.436)
0.330
CD8+ cell density: low
3.408 (0.964–12.044)
0.057
FOXP3+ cell density: high
1.316 (0.490–3.531)
0.586
PD-1+ cell density: high
0.819 (0.301–2.230)
0.696
Primary tumor size: ≥5 cm
0.399 (0.134–1.181)
0.097
Lymph node invasion: positive
1.167 (0.329–4.138)
0.811
Vascular invasion: positive
0.406 (0.127–1.295)
0.128
Neural invasion: positive
3.926 (0.507–30.435)
0.191
Tumor PD-L1 expression, CD3+ cell density, CD8+ cell density, FOXP3+ cell density, and PD1+ cell density are evaluated in KTs, and variables showing values less than 0.05 are presented in italic.
