Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid

Figure 3

CXCL11, IFNA, RSAD2, USP18, IFI44, IFI44L, IFITI, CCL4, and IL2RA expressions in PBMC from IGRA-positive individuals (, black square) or IGRA-negative (, open square) individuals before and after one and six months of INH treatment. Gene expression was assessed by qPCR. (a–i) The median interquartile range of gene expression relative to that of 18S RNA after one and six months of treatment is reported. The statistical analysis was performed using the nonparametric Kruskal-Wallis ANOVA followed by Dunn’s test; . (j) CXCL10 expression detected in PBMC from IGRA-positive individuals () and IGRA-negative individuals () before and after one and six months of INH treatment is presented as the percentage of individuals expressing the gene.

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