Research Article

Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid

Table 1

Genes selected for qPCR analysis.

NoGeneNameSignaling pathwayReported in TBReference

1CCL-4C-C motif chemokine ligand 4Cytokine signaling in immune system, Toll-like receptor signaling pathwayYes[25]
2CXCL-10C-X-C motif chemokine ligand 10Peptide ligand-binding receptors, Toll-like receptor signaling pathway, type II interferon signaling (IFNG)Yes[26, 27]
3CXCL-11C-X-C motif chemokine ligand 11Peptide ligand-binding receptors, Toll-like receptor signaling pathway, type II interferon signaling (IFNG)Yes[24]
4IFI44Interferon-induced protein 44Immune response IFN alpha/beta signaling pathwayYes[19]
5IFI44LInterferon-induced protein like 44Immune response IFN alpha/beta signaling pathwayYes[19, 20]
6IFIT1Interferon-induced with tetraticopeptide repeats 1Immune response IFN alpha/beta signaling pathwayYes[23]
7IFNAInterferon alpha 10Immune response IFN alpha/beta signaling pathwayYes[19]
8IL2RAInterleukin 2 receptor subunit alphaTGF-beta pathway, Th17 cell differentiationYes[22]
9RSAD2Radical S-adenosyl methionine domain-containing 2Immune response IFN alpha/beta signaling pathwayYes[23]
10USP18Ubiquitin-specific peptidase 18Immune response IFN alpha/beta signaling pathway, antiviral mechanism by IFN-stimulated genesYes[21]