Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid

Table 3

qPCR analysis of differentially expressed genes in PBMC from TST-positive individuals after 1 and 6 months of INH therapy.

No.	Gene	Comparison
		t1 vs. t0	t6 vs. t0	t1 vs. t6
1	USP18	Up	Up	—	a, b
2	IL2RA	Up	Up	—	a, b
3	IFI44L	Up	Up	Up	a, b, c
4	IFIT1	—	Up	Up	b, c
5	CXCL-11	Down	Down	—	b
6	CCL4	—	Down	Down	b, c
7	IFI44	Down	Down	Up	a, b, c
8	IFNA	—	Down	Down	b, c
9	RSAD2	—	Down	—	c
10	CXCL-10	—	—	—	NS

Mann-Whitney Test; NS: not significant; a = t1 vs. t0; b = t6 vs. t0; c = t1 vs. t6.