Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Figure 3

Decreased frequencies of Th17 and Tc17 cells among human PBMCs infected with the H7N9 virus at the indicated time points postinfection in vitro. (a) PBMCs isolated from healthy volunteers were infected with the H7N9 or H1N1(2009) virus at the indicated time points after infection; mock-infected and infected cells were gated initially for lymphocytes, and CD4⁺IL-17A⁺ (Th17) and CD8⁺IL-17A⁺ (Tc17) cells were then analyzed. (b, c) Analysis of the proportions of Th17 (b) and Tc17 (c) cells among PBMCs after H7N9 virus infection for 0, 12, 24, and 48 h. (d, e) Analysis of the proportions of Th17 (d) and Tc17 (e) cells among PBMCs after H1N1(2009) virus infection for 0, 12, 24, and 48 h. (f, g) Differences in the frequencies of Th17 (f) and Tc17 (g) cells after H7N9 and H1N1(2009) virus infection for 0, 12, 24, and 48 h. , , and .

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